Contents

GJC1

Protein-coding gene in the species Homo sapiens

GJC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SHW
Identifiers
Aliases	GJC1, CX45, GJA7, gap junction protein gamma 1
External IDs	OMIM: 608655; MGI: 95718; HomoloGene: 4016; GeneCards: GJC1; OMA:GJC1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 44,798,448 bp[1] End 44,830,816 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 102,690,405 bp[2] End 102,710,526 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tail of epididymis seminal vesicula cartilage tissue secondary oocyte visceral pleura saphenous vein placenta ventricular zone epithelium of colon myometrium Top expressed in abdominal wall renal corpuscle internal carotid artery superior surface of tongue vas deferens endocardial cushion tail of embryo external carotid artery medullary collecting duct primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion channel activity gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling gap junction channel activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane intercalated disc plasma membrane cell junction gap junction connexin complex Biological process muscle contraction cell development cardiac muscle tissue development cell-cell signaling vasculogenesis cell communication heart development ion transmembrane transport atrial cardiac muscle cell action potential cell-cell junction assembly visual perception chemical synaptic transmission gap junction assembly SA node cell to atrial cardiac muscle cell communication by electrical coupling AV node cell to bundle of His cell communication by electrical coupling transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10052 14615 Ensembl ENSG00000182963 ENSMUSG00000034520 UniProt P36383 P28229 RefSeq (mRNA) NM_001080383 NM_005497 NM_001159382 NM_001159383 NM_008122 NM_001359040 RefSeq (protein) NP_001073852 NP_005488 NP_001152854 NP_001152855 NP_032148 NP_001345969 Location (UCSC) Chr 17: 44.8 – 44.83 Mb Chr 11: 102.69 – 102.71 Mb PubMed search [3] [4]
Wikidata
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Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) — is a protein that in humans is encoded by the GJC1 gene.^[5][6]

Function[edit]

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described.^[6]

References[edit]

Further reading[edit]

External links[edit]

• GJC1 human gene location in the UCSC Genome Browser.
• GJC1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.