Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.[5][6][7][8]
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.[8]
HCN1 channel expression is found in the sinoatrial node,[9][10] the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.[11][12][13][14][15]
HCN1 has been shown to interact with HCN2.[20][21]
De novo mutations in HCN1 cause epilepsy.[22]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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PDB gallery
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1q3e: HCN2J 443-645 in the presence of cGMP
1q43: HCN2I 443-640 in the presence of cAMP, selenomethionine derivative
1q5o: HCN2J 443-645 in the presence of cAMP, selenomethionine derivative
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