Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.[5][6]
TRPM5 is a calcium-activated non-selective cation channel that induces depolarization upon increases in intracellular calcium, it is a signal mediator in chemosensory cells. Channel activity is initiated by a rise in the intracellular calcium, and the channel permeates monovalent cations as K+ and Na+. TRPM5 is a key component of taste transduction in the gustatory systemofbitter, sweet and umami tastes being activated by high levels of intracellular calcium. It has also been targeted as a possible contributor to fat taste signaling.[7][8] The calcium dependent opening of TRPM5 produces a depolarizing generator potential which leads to an action potential.[9]
TRPM5 is expressed in pancreatic β-cells[10] where it is involved in the signaling mechanism for insulin secretion. The potentiation of TRPM5 in the β-cells leads to increased insulin secretion and protects against the development of type 2 diabetes in mice.[11] Further expression of TRPM5 can be found in tuft cells,[12] solitary chemosensory cells and several other cell types in the body that have a sensory role.
The role of TRPM5 in the pancreatic β-cell makes it a target for the development of novel antidiabetic therapies.[13]
Selective blocking agents of TRPM5 ion channels can be used to identify TRPM5 currents in primary cells. Most identified compounds show, however, a poor selectivity between TRPM4 and TRPM5 or other ion channels.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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see also disorders |
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TRPA |
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TRPC |
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TRPM |
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TRPML |
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TRPP |
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TRPV |
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See also: Receptor/signaling modulators • Ion channel modulators |