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Contents

   



(Top)
  


1 See also  




2 References  













PF-592,379






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From Wikipedia, the free encyclopedia
  

PF-592,379
Clinical data
Routes of
administration		Oral
Legal status
Legal status
  • Investigational (discontinued)
Identifiers

  • 5-[(2R,5S)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine

CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H21N3O
Molar mass235.331 g·mol−1
3D model (JSmol)

  • CCCN([C@@H](C)CO1)C[C@H]1C2=CN=C(N)C=C2

  • InChI=1S/C13H21N3O/c1-3-6-16-8-12(17-9-10(16)2)11-4-5-13(14)15-7-11/h4-5,7,10,12H,3,6,8-9H2,1-2H3,(H2,14,15)/t10-,12-/m0/s1

  • Key:DFTCYTDJDXZFSK-JQWIXIFHSA-N

PF-592,379 is a drug developed by Pfizer which acts as a potent, selective and orally active agonist for the dopamine D3 receptor, which was under development as a potential medication for the treatment of female sexual dysfunction and male erectile dysfunction. Unlike some other less selective D3 agonists, a research study showed that PF-592,379 has little abuse potential in animal studies, and so was selected for further development and potentially human clinical trials.[1][2] Development has since been discontinued.[3]

See also[edit]

References[edit]

  1. ^ Attkins N, Betts A, Hepworth D, Heatherington AC (November 2010). "Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 40 (11): 730–42. doi:10.3109/00498254.2010.514961. PMID 20836725. S2CID 30288414.
  • ^ Collins GT, Butler P, Wayman C, Ratcliffe S, Gupta P, Oberhofer G, Caine SB (June 2012). "Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats". Behavioural Pharmacology. 23 (3): 280–91. doi:10.1097/FBP.0b013e3283536d21. PMC 3365486. PMID 22470105.
  • ^ "Drug Profile: PF 592379". Adis Insight. Springer Nature Switzerland AG.

    • Retrieved from "https://en.wikipedia.org/w/index.php?title=PF-592,379&oldid=1232174389"
    Categories: 
    ●Dopamine agonists
     ●Female sexual dysfunction drugs
     ●Morpholines
     ●Drugs developed by Pfizer
     ●Abandoned drugs
     ●Aminopyridines
     ●Aphrodisiacs
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