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SCH-23390






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From Wikipedia, the free encyclopedia
  

SCH-23390
Names
IUPAC name

7-chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol

Identifiers

CAS Number

3D model (JSmol)
ChEBI
ChEMBL

IUPHAR/BPS

PubChem CID
UNII

CompTox Dashboard (EPA)

  • CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Cl

Properties

Chemical formula

 C17H18ClNO
Molar mass 287.78 g/mol

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

☒N verify (what is checkY☒N ?)

Infobox references

SCH-23390 also known as halobenzazepine, is a synthetic compound that acts as a D1 receptor antagonist and has either minimal or negligible effects on the D2 receptor.

In a 1990 study in rats SCH-23390 offered significant protection from death in dextroamphetamine overdosage, without providing protection from death by methamphetamine overdose. The compound provided significant protection from cocaine overdose in rats only at the lowest dose tested in the measurement series. This suggested that D-amphetamine and methamphetamine at high (lethal) doses have different mechanisms of toxicity in rats.[1]

References

[edit]
  1. ^ Derlet, R. W.; Albertson, T. E.; Rice, P. (1990). "The Effect of SCH 23390 Against Toxic Doses of Cocaine, d-Amphetamine and Methamphetamine". Life Sciences. 47 (9): 821–827. doi:10.1016/0024-3205(90)90555-6. PMID 2215083.


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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=SCH-23390&oldid=1078560394"
    Categories: 
    ●D1 antagonists
     ●1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
     ●Chloroarenes
     ●Nervous system drug stubs
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    ●This page was last edited on 22 March 2022, at 05:43 (UTC).
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