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ABT-670

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ABT-670
Identifiers

IUPAC name 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide
CAS Number	630119-43-6^N
PubChem CID	16094676
ChemSpider	17252978^Y
UNII	4L6071XH2J
ChEMBL	ChEMBL219182^Y
CompTox Dashboard (EPA)	DTXSID30212235
Chemical and physical data
Formula	C₁₉H₂₃N₃O₂
Molar mass	325.412 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES [O-][n+]1ccccc1C(CC3)CCN3CNC(=O)c(c2)cccc2C
InChI InChI=1S/C19H23N3O2/c1-15-5-4-6-17(13-15)19(23)20-14-21-11-8-16(9-12-21)18-7-2-3-10-22(18)24/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,20,23)^Y Key:PUMMPCXNEPHBNN-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

ABT-670 is a drug which acts as a potent, orally bioavailable dopamine agonist selective for the D₄ subtype, which was developed as a possible treatment for erectile dysfunction,^[1] although its current uses are limited to scientific research.^[2]

References[edit]

^ Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, et al. (December 2006). "Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction". Journal of Medicinal Chemistry. 49 (25): 7450–65. doi:10.1021/jm060662k. PMID 17149874.

^ Richards N, Wayman C, Allers KA (November 2009). "Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection". Neuroscience Letters. 465 (3): 242–7. doi:10.1016/j.neulet.2009.08.078. PMID 19733217. S2CID 27767274.

Drugs for erectile dysfunction (G04BE) and premature ejaculation

For erectile dysfunction

Prostaglandins (E)	Alprostadil
PDE5 inhibitors	Avanafil Sildenafil Tadalafil Udenafil Vardenafil
Alpha blockers	Moxisylyte Phentolamine Yohimbine
Dopamine agonists	Apomorphine
Melanocortin agonists	Bremelanotide Melanotan II PL-6983
Others	Afrodor (acecarbromal, quebracho, vitamin E) Papaverine