IL10RA | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | IL10RA, CD210, CD210a, CDW210A, HIL-10R, IL-10R1, IL10R, Interleukin 10 receptor, alpha subunit, interleukin 10 receptor subunit alpha | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 146933; MGI: 96538; HomoloGene: 1196; GeneCards: IL10RA; OMA:IL10RA - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA is its human gene.
IL10RA has also been designated CDw210a (cluster of differentiation w210a).
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of myeloid progenitor cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylationofJAK1 and TYK2 kinases.[5]
Interleukin 10 receptor, alpha subunit has been shown to interact with:
PDB gallery
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1j7v: HUMAN IL-10 / IL-10R1 COMPLEX
1lqs: CRYSTAL STRUCTURE OF HUMAN CYTOMEGALOVIRUS IL-10 BOUND TO SOLUBLE HUMAN IL-10R1
1y6k: Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain
1y6m: Crystal structure of Epstein-Barr virus IL-10 complexed with the soluble IL-10R1 chain
1y6n: Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain
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Chemokine receptor (GPCRs) |
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TNF receptor |
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JAK-STAT |
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Ig superfamily |
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IL 17 family |
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Enzyme-linked receptor |
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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