Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene.[5][6][7]
The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2, encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor.[5]
Interferon gamma receptor 1 has been shown to interact with Interferon-gamma.[8][9]
Mutations in the IFNGR1 gene can lead to extreme susceptibility to Mycobacterial infections.[10][11] All known mutations and common variations in the IFNGR1 are present in the IFNGR1 mutation database.[12][13]
PDB gallery
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1fg9: 3:1 COMPLEX OF INTERFERON-GAMMA RECEPTOR WITH INTERFERON-GAMMA DIMER
1fyh: 1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR
1jrh: COMPLEX (ANTIBODY/ANTIGEN)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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