Contents

CD27

Member of the tumor necrosis factor receptor superfamily.

CD27
Identifiers
Aliases	CD27, S152, S152. LPFS2, T14, TNFRSF7, Tp55, CD27 molecule
External IDs	OMIM: 186711; MGI: 88326; HomoloGene: 74386; GeneCards: CD27; OMA:CD27 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,444,955 bp[1] End 6,451,718 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 59.32 cM Start 125,209,585 bp[2] End 125,213,973 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node spleen appendix bone marrow cells granulocyte blood duodenum testicle mucosa of transverse colon tonsil Top expressed in thymus spleen epithelium of small intestine intestinal villus Ileal epithelium pharynx granulocyte bone marrow spermatid neck More reference expression data BioGPS More reference expression data
Gene ontology Molecular function tumor necrosis factor-activated receptor activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein binding transmembrane signaling receptor activity Cellular component extracellular region integral component of membrane integral component of plasma membrane membrane cell surface plasma membrane external side of plasma membrane Biological process negative regulation of apoptotic process response to lipopolysaccharide response to ethanol negative regulation of T cell apoptotic process extrinsic apoptotic signaling pathway regulation of cell population proliferation cell surface receptor signaling pathway apoptotic process tumor necrosis factor-mediated signaling pathway immunoglobulin mediated immune response positive regulation of JNK cascade inflammatory response immune response negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of B cell differentiation positive regulation of T cell differentiation multicellular organism development positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 939 21940 Ensembl ENSG00000139193 ENSMUSG00000030336 UniProt P26842 P41272 RefSeq (mRNA) NM_001242 NM_001033126 NM_001042564 NM_001286753 RefSeq (protein) NP_001233 NP_001028298 NP_001036029 NP_001273682 Location (UCSC) Chr 12: 6.44 – 6.45 Mb Chr 6: 125.21 – 125.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD27 is a member of the tumor necrosis factor receptor superfamily.^[5] It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule, and is the target of an anti-cancer drug in clinical trials.^[6]

During mouse embryonic development, specific (medium) expression levels of CD27 (in addition to high cKit,^[7][8] medium Gata2,^[9][10][8] and high CD31^[8] expression levels) define the very first adult definitive hematopoietic stem cells generated in the aorta-gonad-mesonephros region.^[8] Furthermore, CD27 is expressed on both naïve and activated effector T cells as well as NK cells and activated B cells.^[5] It is a type I transmembrane protein with cysteine-rich domains, but once T cells have become activated, a soluble form of CD27 can be shed.^[5][6]

The protein encoded by this gene is a member of the TNF-receptor superfamily.^[11] This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.^[5]

When CD27 binds CD70, a signaling cascade leads to the differentiation and clonal expansion of T cells.^[11] The cascade also results in improved survival and memory of cytotoxic T cells and increased production of certain cytokines.^[12] This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK.^[11] Adaptor proteins TRAF2, TRAF3, and TRAF5 have been shown to mediate the signaling process of this receptor via ubiquitination.^[5][6] CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.^[13]

In murine γδ T cells its expression has been correlated with the secretion of IFNγ.^[14]

Varlilumab is an IgG1 antibody that binds to CD27 and is an experimental cancer treatment.^[6] This agonist antibody stimulates CD27 when it binds.^[6] The drug is in early clinical trials and appears to stimulate T cells and increase production of cytokines such as interferon-gamma.^[6][11]

CD27 has been shown to interact with SIVA1,^[15] TRAF2^[16][17] and TRAF3.^[16][17]

Some mutations can decrease the expression of CD27. Three such mutations, C53Y, C96Y, and R107C, are located in the cysteine-rich domains of CD27.^[5]

• CD27+Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CD27 genome location and CD27 gene details page in the UCSC Genome Browser.

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