Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.[5]
ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.[6]
In mammals the integrins that include alpha-V are :
Name | Synonyms | Distribution | Ligands |
αVβ1 | neurological tumors | vitronectin; fibrinogen | |
αVβ3 | vitronectin receptor[7] | activated endothelial cells, melanoma, glioblastoma | vitronectin,[7] fibronectin, fibrinogen, osteopontin, Cyr61 |
αVβ5 | widespread, esp. fibroblasts, epithelial cells | vitronectin and adenovirus | |
αVβ6 | proliferating epithelia, esp. lung and mammary gland | fibronectin; TGFβ1+3 | |
αVβ8 | neural tissue; peripheral nerve | fibronectin; TGFβ1+3 |
Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer,[8] and prostate cancer.[9]
The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.[10]
PDB gallery
| |
---|---|
1jv2: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3
1l5g: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND
1m1x: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+
1u8c: A novel adaptation of the integrin PSI domain revealed from its crystal structure
|
| |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alpha |
| ||||||||||||
Beta |
| ||||||||||||
Dimers |
| ||||||||||||
see also cell surface receptor deficiencies |
![]() | This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |