CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.[5][6]
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.[7]
Defects in this gene cause severe immunodeficiency.[8][9] This gene has also been linked to a susceptibility to type I diabetes in women.[10]
T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B,[11] CD3EAP[12] and NCK2.[13]
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PDB gallery
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1xiw: Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
