Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.[5] CD61 is a cluster of differentiation found on thrombocytes.[6]
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.[7]
Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.[8]
CD61 has been shown to interact with PTK2,[9][10] ITGB3BP,[11][12] TLN1[13][14] and CIB1.[15]
PDB gallery
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1jv2: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3
1l5g: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND
1m1x: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+
1m8o: Platelet integrin alfaIIb-beta3 cytoplasmic domain
1txv:
1ty3:
1ty5:
1ty6:
1ty7:
1tye: Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
1u8c: A novel adaptation of the integrin PSI domain revealed from its crystal structure
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Coagulation factors |
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Anticoagulant factors |
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Fibrinolytic factors |
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Coagulation markers |
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Alpha |
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Beta |
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Dimers |
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see also cell surface receptor deficiencies |
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