Contents

VPREB1

Protein-coding gene in the species Homo sapiens

VPREB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H32, 2H3N, 3BJ9
Identifiers
Aliases	VPREB1, IGI, IGVPB, VPREB, CD179a, pre-B lymphocyte 1, V-set pre-B cell surrogate light chain 1
External IDs	OMIM: 605141; MGI: 98936; HomoloGene: 84741; GeneCards: VPREB1; OMA:VPREB1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.22 Start 22,244,780 bp[1] End 22,245,515 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A3|16 10.46 cM Start 16,686,267 bp[2] End 16,688,707 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle bone marrow bone marrow cells trabecular bone granulocyte lymph node tonsil blood cecum appendix Top expressed in choroid plexus choroid plexus of fourth ventricle bone marrow embryo embryo granulocyte right kidney morula thymus human kidney More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 7441 22362 Ensembl ENSG00000169575 ENSMUSG00000059305 UniProt P12018 P13372 RefSeq (mRNA) NM_007128 NM_001303509 NM_016982 RefSeq (protein) NP_001290438 NP_009059 NP_058678 Location (UCSC) Chr 22: 22.24 – 22.25 Mb Chr 16: 16.69 – 16.69 Mb PubMed search [3] [4]
Wikidata
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Immunoglobulin iota chain is a protein that in humans is encoded by the VPREB1 gene.^[5][6] VPREB1 has also recently been designated CD179A (cluster of differentiation 179A).

CD179a (VpreB) is a 126 aa-long polypeptide with apparent MW of 16-18 kDa. It is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. CD179a has an Ig V domain-like structure, but lacks the last beta-strand (beta7) of a typical V domain. Instead, it has a carboxyl terminal end that shows no sequence homologies to any other proteins. CD179a associates non-covalently with CD179b (lambda5 or lambda-like) carrying an Ig C domain-like structure to form an Ig light chain-like structure, which is called the surrogate light chain or pseudo light chain. In this complex, the incomplete V domain of CD179a appears to be complemented by the extra beta7 strand of CD179b. On the surface of early preB cells, CD179a/CD179b surrogate light chain is disulfide-linked to membrane-bound Ig mu heavy chain in association with a signal transducer CD79a/CD79b heterodimer to form a B cell receptor-like structure, so-called preB cell receptor (preBCR). Though no CD179a-related human disease or pathology has been reported yet, the deficiency of other components of preB cell receptor such as CD179b, Ig mu heavy chain and CD79a has been shown to result in severe impairment of B cell development and agammaglobulinemia in human. PreBCR transduces signals for: 1) cellular proliferation, differentiation from the proB cell to preB cell stage, 2) allelic exclusion at the Ig heavy chain gene locus, and 3) promotion of Ig light chain gene rearrangements. Thus, preBCR functions as a checkpoint in early B cell development to monitor the production of Ig mu heavy chain through a functional rearrangement of Ig heavy chain gene as well as the potency of Ig mu heavy chain to associate with Ig light chain.^[6]

• Overview of all the structural information available in the PDB for UniProt: P12018 (Human Immunoglobulin iota chain) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.