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IGLL1

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IGLL1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2H32, 2H3N, 2LKQ

Identifiers

Aliases

IGLL1, 14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2, immunoglobulin lambda like polypeptide 1

External IDs

OMIM: 146770; MGI: 96529; HomoloGene: 131669; GeneCards: IGLL1; OMA:IGLL1 - orthologs

Gene location (Human)

Chr.	Chromosome 22 (human)^[1]

Band	22q11.23	Start	23,573,125 bp^[1]
Band	22q11.23	End	23,580,302 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16 A3\|16 10.45 cM	Start	16,678,535 bp^[2]
Band	16 A3\|16 10.45 cM	End	16,681,849 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bone marrow

bone marrow cells

testicle

left testis

right testis

trabecular bone

thymus

monocyte

lymph node

spleen

Top expressed in

bone marrow

granulocyte

embryo

choroid plexus

brown adipose tissue

choroid plexus of fourth ventricle

Region I of hippocampus proper

inferior colliculus

secondary oocyte

CA3 field

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	immunoglobulin receptor binding antigen binding
Cellular component	blood microparticle membrane external side of plasma membrane immunoglobulin complex, circulating extracellular region
Biological process	B cell receptor signaling pathway phagocytosis, recognition positive regulation of B cell activation phagocytosis, engulfment innate immune response defense response to bacterium immune response complement activation, classical pathway leukocyte migration
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3543


16136

Ensembl


ENSG00000128322


ENSMUSG00000075370

UniProt


P15814


P20764

RefSeq (mRNA)


NM_020070 NM_152855 NM_001369906


NM_001190325

RefSeq (protein)


NP_064455 NP_690594 NP_001356835


NP_001177254

Location (UCSC)

Chr 22: 23.57 – 23.58 Mb

Chr 16: 16.68 – 16.68 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Immunoglobulin lambda-like polypeptide 1 is a protein that in humans is encoded by the IGLL1 gene.^[5]^[6]^[7] IGLL1 has also recently been designated CD179B (cluster of differentiation 179B).

It is associated with agammaglobulinemia-2.

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128322 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000075370 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM, Melchers F (Nov 1988). "The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments". Immunogenetics. 28 (5): 328–33. doi:10.1007/BF00364231. PMID 3139558. S2CID 6981867.

^ Schiff C, Milili M, Fougereau M (Dec 1989). "Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver". Eur J Immunol. 19 (10): 1873–8. doi:10.1002/eji.1830191018. PMID 2511029. S2CID 84544002.

^ ^a ^b "Entrez Gene: IGLL1 immunoglobulin lambda-like polypeptide 1".

Further reading[edit]

Evans RJ, Hollis GF (1991). "Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution". J. Exp. Med. 173 (2): 305–11. doi:10.1084/jem.173.2.305. PMC 2118775. PMID 1703205.

Bossy D, Milili M, Zucman J, et al. (1992). "Organization and expression of the lambda-like genes that contribute to the mu-psi light chain complex in human pre-B cells". Int. Immunol. 3 (11): 1081–90. doi:10.1093/intimm/3.11.1081. PMID 1760403.

Mattei MG, Fumoux F, Roeckel N, et al. (1991). "The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus". Genomics. 9 (3): 544–6. doi:10.1016/0888-7543(91)90422-B. PMID 1903358.

Tsubata T, Reth M (1990). "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface". J. Exp. Med. 172 (3): 973–6. doi:10.1084/jem.172.3.973. PMC 2188549. PMID 2117639.

Schiff C, Bensmana M, Guglielmi P, et al. (1991). "The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene". Int. Immunol. 2 (3): 201–7. doi:10.1093/intimm/2.3.201. PMID 2128466.

Hollis GF, Evans RJ, Stafford-Hollis JM, et al. (1989). "Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5552–6. Bibcode:1989PNAS...86.5552H. doi:10.1073/pnas.86.14.5552. PMC 297661. PMID 2501791.

Chang H, Dmitrovsky E, Hieter PA, et al. (1986). "Identification of three new Ig lambda-like genes in man". J. Exp. Med. 163 (2): 425–35. doi:10.1084/jem.163.2.425. PMC 2188038. PMID 3003227.

Ohnishi K, Takemori T (1994). "Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines". J. Biol. Chem. 269 (45): 28347–53. doi:10.1016/S0021-9258(18)46934-7. PMID 7961773.

Bauer TR, McDermid HE, Budarf ML, et al. (1993). "Physical location of the human immunoglobulin lambda-like genes, 14.1, 16.1, and 16.2" (PDF). Immunogenetics. 38 (6): 387–99. doi:10.1007/BF00184519. hdl:2027.42/46751. PMID 8406611. S2CID 19311673.

Sohi MK, Corper AL, Wan T, et al. (1996). "Crystallization of a complex between the Fab fragment of a human immunoglobulin M (IgM) rheumatoid factor (RF-AN) and the Fc fragment of human IgG4". Immunology. 88 (4): 636–41. doi:10.1046/j.1365-2567.1996.d01-692.x. PMC 1456622. PMID 8881769.

Donohoe ME, Blomberg BB (1997). "The 14.1 surrogate light chain promoter has lineage- and stage-restricted activity". J. Immunol. 158 (4): 1681–91. doi:10.4049/jimmunol.158.4.1681. PMID 9029104. S2CID 29592657.

Kawasaki K, Minoshima S, Nakato E, et al. (1997). "One-megabase sequence analysis of the human immunoglobulin lambda gene locus". Genome Res. 7 (3): 250–61. doi:10.1101/gr.7.3.250. PMID 9074928.

Corper AL, Sohi MK, Bonagura VR, et al. (1997). "Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction". Nat. Struct. Biol. 4 (5): 374–81. doi:10.1038/nsb0597-374. PMID 9145108. S2CID 34331252.

Minegishi Y, Coustan-Smith E, Wang YH, et al. (1998). "Mutations in the Human λ5/14.1 Gene Result in B Cell Deficiency and Agammaglobulinemia". J. Exp. Med. 187 (1): 71–7. doi:10.1084/jem.187.1.71. PMC 2199185. PMID 9419212.

Miyazaki T, Kato I, Takeshita S, et al. (1999). "Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines". Int. Immunol. 11 (8): 1195–202. doi:10.1093/intimm/11.8.1195. PMID 10421777.

Donohoe ME, Beck-Engeser GB, Lonberg N, et al. (2000). "Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype". J. Immunol. 164 (10): 5269–76. doi:10.4049/jimmunol.164.10.5269. PMID 10799888.

Nomura K, Kanegane H, Karasuyama H, et al. (2000). "Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway". Blood. 96 (2): 610–7. PMID 10887125.

Fang T, Smith BP, Roman CA (2001). "Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression". J. Immunol. 167 (7): 3846–57. doi:10.4049/jimmunol.167.7.3846. PMID 11564802.

v t e PDB gallery
2h32: Crystal structure of the pre-B cell receptor 2h3n: Crystal structure of a surrogate light chain (LAMBDA5 and VpreB) homodimer

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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