CD7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | CD7, GP40, LEU-9, TP41, Tp40, CD7 molecule | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 186820; MGI: 88344; HomoloGene: 4471; GeneCards: CD7; OMA:CD7 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.[5]
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[5]
CD7 has been shown to interact with PIK3R1.[6][7]
CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.[8] Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).[9]
Cluster of differentiation by lineage
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Lymphoid |
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Myeloid |
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Stem cell |
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