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(Top) 1 Use in dogs 2 See also 3 References

Demecarium bromide

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Demecarium bromide
Clinical data

Trade names	Humorsol
Routes of administration	Topical (ophthalmic solution)
ATC code	S01EB04 (WHO)
Identifiers
IUPAC name Trimethyl-[3-[methyl-[10-[methyl-(3-trimethylammoniophenoxy)carbonyl-amino]decyl]carbamoyl]oxyphenyl]ammonium dibromide
CAS Number	56-94-0^Y
PubChem CID	5965
DrugBank	DB00944^Y
ChemSpider	5750^Y
UNII	61D5V4OKTP
KEGG	D00667^Y
ChEBI	CHEBI:4391^Y
ChEMBL	ChEMBL1200514^N
CompTox Dashboard (EPA)	DTXSID6045240
ECHA InfoCard	100.000.274
Chemical and physical data
Formula	C₃₂H₅₂Br₂N₄O₄
Molar mass	716.600 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES [Br-].[Br-].O=C(Oc1cccc(c1)[N+](C)(C)C)N(CCCCCCCCCCN(C(=O)Oc2cccc(c2)[N+](C)(C)C)C)C
InChI InChI=1S/C32H52N4O4.2BrH/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8;;/h17-22,25-26H,9-16,23-24H2,1-8H3;2*1H/q+2;;/p-2^Y Key:YHKBUDZECQDYBR-UHFFFAOYSA-L^Y
^NY (what is this?) (verify)

Demecarium bromide, trade name Humorsol, is a carbamate parasympathomimetic drug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma medication. It is applied directly to the eye in order to reduce elevated intraocular pressure associated with glaucoma.^[1]

Demecarium causes constriction of the pupil (miosis), which improves the drainage of the fluid in the eye (aqueous humour).^[2] As demecarium reversibly inhibits cholinesterase, it can be administered less frequently than other parasympathomimetic drugs, such as carbachol.^[3]

Commercially produced demecarium bromide solution, previously sold under the trade name Humorsol,^[4] is no longer available,^[3] although solutions of demecarium can be compounded.^[5]

Use in dogs

[edit]

When administered with a topical corticosteroid, demecarium can delay the onset of primary glaucoma in dogs.^[3] High doses of demecarium may cause organophosphate toxicity, particularly if flea treatments containing organophosphates are administered at the same time.^[3]

References

[edit]

^ Jeske AH, ed. (2014). "Demecarium bromide". Mosby's dental drug reference (11th ed.). St. Louis, Missouri: Elsevier Mosby. p. 374. ISBN 978-0-323-16916-5.

^ Stein HA, Stein RM, Freeman M (2012). "Demecarium bromide (Humorsol)". Ophthalmic dictionary and vocabulary builder for eye care professionals (4th ed.). New Delhi: Jaypee Brothers Medical. p. 103. ISBN 9789350253656.

^ ^a ^b ^c ^d Maggs DJ, Miller PE, Ofri R (2013). "Indirect-acting parasympathomimetic agents". Slatter's Fundamentals of Veterinary Ophthalmology (5th ed.). St. Louis, Missouri: Elsevier. p. 51. ISBN 978-1-4377-2367-0.

^ Edmunds MW, Mayhew MS (2013). Pharmacology for the primary care provider (4th ed.). Elsevier Health Sciences. p. 174. ISBN 978-0-323-08790-2.

^ Alario AF, Strong TD, Pizzirani S (November 2015). "Medical Treatment of Primary Canine Glaucoma". The Veterinary Clinics of North America. Small Animal Practice. 45 (6): 1235–59, vi. doi:10.1016/j.cvsm.2015.06.004. PMID 26319445.