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Contents

   



(Top)
  


1 Function  




2 References  




3 Further reading  




4 External links  













FOXF1






●العربية
 ●مصرى
 ●Татарча / tatarça
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From Wikipedia, the free encyclopedia
  

FOXF1

Identifiers

Aliases

FOXF1, ACDMPV, FKHL5, FREAC1, forkhead box F1

External IDs

OMIM: 601089; MGI: 1347470; HomoloGene: 1114; GeneCards: FOXF1; OMA:FOXF1 - orthologs

Gene location (Human)

Chromosome 16 (human)

Chr.

Chromosome 16 (human)[1]

Chromosome 16 (human)

Genomic location for FOXF1

Genomic location for FOXF1

Band

16q24.1

Start

86,510,527 bp[1]

End

86,515,422 bp[1]

Gene location (Mouse)

Chromosome 8 (mouse)

Chr.

Chromosome 8 (mouse)[2]

Chromosome 8 (mouse)

Genomic location for FOXF1

Genomic location for FOXF1

Band

8 E1|8 70.31 cM

Start

121,811,125 bp[2]

End

121,814,883 bp[2]

Bgee

Mouse (ortholog)

  • muscle layer of sigmoid colon

  • gastric mucosa

  • right lung

  • lower lobe of lung

  • urinary bladder

  • mucosa of urinary bladder

  • buccal mucosa cell

  • upper lobe of lung

  • upper lobe of left lung

  • pylorus
    • right lung lobe

  • left lung lobe

  • migratory enteric neural crest cell

  • molar

  • somatopleuric mesenchyme

  • lamina propria of urethra

  • mandibular prominence

  • urinary bladder

  • extraembryonic membrane

  • yolk sac

    • More reference expression data

    BioGPS

    More reference expression data

    Molecular function

  • sequence-specific DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • DNA-binding transcription factor activity
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific

    • Cellular component

  • nucleus

    • Biological process

  • regulation of smooth muscle cell differentiation
  • renal system development
  • ureter development
  • regulation of transcription, DNA-templated
  • lung morphogenesis
  • embryonic foregut morphogenesis
  • lung development
  • positive regulation of cell migration
  • endocardial cushion development
  • cellular response to organic cyclic compound
  • extracellular matrix organization
  • cardiac left ventricle morphogenesis
  • in utero embryonic development
  • negative regulation of transcription by RNA polymerase II
  • negative regulation of mast cell degranulation
  • smooth muscle cell differentiation
  • morphogenesis of a branching structure
  • venous blood vessel development
  • cellular response to cytokine stimulus
  • right lung morphogenesis
  • transcription, DNA-templated
  • vasculogenesis
  • positive regulation of transcription, DNA-templated
  • respiratory tube development
  • heart development
  • determination of left/right symmetry
  • establishment of epithelial cell apical/basal polarity
  • blood vessel development
  • embryonic ectodermal digestive tract morphogenesis
  • positive regulation of mesenchymal cell proliferation
  • embryonic digestive tract morphogenesis
  • animal organ morphogenesis
  • pancreas development
  • detection of wounding
  • mesenchyme migration
  • smoothened signaling pathway
  • lateral mesodermal cell differentiation
  • lung alveolus development
  • digestive tract development
  • lung vasculature development
  • mesoderm development
  • epithelial tube branching involved in lung morphogenesis
  • negative regulation of inflammatory response
  • lung lobe morphogenesis
  • ductus arteriosus closure
  • embryonic digestive tract development
  • positive regulation of transcription by RNA polymerase II
  • epithelial cell differentiation involved in mammary gland alveolus development
  • midgut development
  • positive regulation of cell-substrate adhesion
  • transcription by RNA polymerase II
  • cell differentiation
  • cell-cell adhesion
  • trachea development

    • Sources:Amigo / QuickGO

    Species

    Human

    Mouse

    Entrez

    2294

    15227

    Ensembl

    ENSG00000103241

    ENSMUSG00000042812

    UniProt

    Q12946

    Q61080

    RefSeq (mRNA)

    NM_001451

    NM_010426

    RefSeq (protein)

    NP_001442

    NP_034556

    Location (UCSC)

    Chr 16: 86.51 – 86.52 Mb

    Chr 8: 121.81 – 121.81 Mb

    PubMed search

    [3]

    [4]

    Wikidata

    Forkhead box protein F1 (FOXF1) is a protein that in humans is encoded by the FOXF1 gene.[5][6][7]

    Function[edit]

    This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. FOX1 protein is important in the development of the pulmonary mesenchyme and the development of the gastrointestinal tract.[8]

    References[edit]

    1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103241 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042812 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ Larsson C, Hellqvist M, Pierrou S, White I, Enerbäck S, Carlsson P (Dec 1995). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics. 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID 8825632.
  • ^ Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (Oct 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.
  • ^ "Entrez Gene: FOXF1 forkhead box F1".
  • ^ "FOXF1 gene: MedlinePlus Genetics". medlineplus.gov. Retrieved 2021-06-10.

    • Further reading[edit]

    • Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W, Thies U (Jun 1994). "Human brain factor 1, a new member of the fork head gene family". Genomics. 21 (3): 551–7. doi:10.1006/geno.1994.1313. PMID 7959731.
  • Hellqvist M, Mahlapuu M, Samuelsson L, Enerbäck S, Carlsson P (Feb 1996). "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2". The Journal of Biological Chemistry. 271 (8): 4482–90. doi:10.1074/jbc.271.8.4482. PMID 8626802.
  • Hellqvist M, Mahlapuu M, Blixt A, Enerbäck S, Carlsson P (Sep 1998). "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB". The Journal of Biological Chemistry. 273 (36): 23335–43. doi:10.1074/jbc.273.36.23335. PMID 9722567.
  • Mahlapuu M, Pelto-Huikko M, Aitola M, Enerbäck S, Carlsson P (Oct 1998). "FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces". Developmental Biology. 202 (2): 183–95. doi:10.1006/dbio.1998.9010. PMID 9769171.
  • Coon DR, Roberts DJ, Loscertales M, Kradin R (Apr 2006). "Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia". Experimental and Molecular Pathology. 80 (2): 119–23. doi:10.1016/j.yexmp.2005.12.003. PMID 16448649.
  • Lomenick JP, Hubert MA, Handwerger S (Nov 2006). "Transcription factor FOXF1 regulates growth hormone variant gene expression". American Journal of Physiology. Endocrinology and Metabolism. 291 (5): E947-51. doi:10.1152/ajpendo.00128.2006. PMID 16772323.

    • External links[edit]


    Stub icon

    This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

  • t
  • e

    • This article incorporates text from the United States National Library of Medicine, which is in the public domain.

    (1) Basic domains

    (1.1) Basic leucine zipper (bZIP)

  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • AP-1
  • BACH
  • BATF
  • BLZF1
  • C/EBP
  • CREB
  • CREM
  • DBP
  • DDIT3
  • GABPA
  • GCN4
  • HLF
  • MAF
  • NFE
  • NFIL3
  • NRL
  • NRF
  • XBP1

    • (1.2) Basic helix-loop-helix (bHLH)

    Group A

  • ASCL2
  • ATOH1
  • HAND
  • MESP2
  • Myogenic regulatory factors
  • NeuroD
  • Neurogenins
  • OLIG
  • Paraxis
  • SLC
  • Twist

    • Group B

  • Myc
  • MXD4
  • TCF4

    • Group C
    bHLH-PAS

  • AHRR
  • ARNT
  • CLOCK
  • HIF
  • NPAS
  • PER
  • SIM

    • Group D

    • BHLH
  • 3
  • 9
  • Pho4
  • ID

    • Group E

    • HES
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • HEY

    • Group F
    bHLH-COE

    (1.3) bHLH-ZIP

  • MAX
  • MITF
  • MNT
  • MLX
  • MLXIPL
  • MXI1
  • Myc
  • SREBP
  • USF1

    • (1.4) NF-1

  • B
  • C
  • X
  • SMAD

    • (1.5) RF-X

    • RFX
  • 2
  • 3
  • 4
  • 5
  • 6
  • ANK

    • (1.6) Basic helix-span-helix (bHSH)

  • β
  • γ
  • δ
  • ε

    • (2) Zinc finger DNA-binding domains

    (2.1) Nuclear receptor (Cys4)

    subfamily 1

  • β
  • CAR
  • FXR
  • LXR
  • PPAR
  • PXR
  • RAR
  • ROR
  • Rev-ErbA
  • VDR

    • subfamily 2

  • II
  • Ear-2
  • HNF4
  • PNR
  • RXR
  • Testicular receptor
  • TLX

    • subfamily 3

  • Estrogen
  • Glucocorticoid
  • Mineralocorticoid
  • Progesterone
  • Estrogen related

    • subfamily 4

  • NOR1
  • NURR1

    • subfamily 5

  • SF1

    • subfamily 6

    subfamily 0

  • SHP

    • (2.2) Other Cys4

  • 2
  • 3
  • 4
  • 5
  • 6
  • MTA
  • TRPS1

    • (2.3) Cys2His2

  • TFIIB
  • TFIID
  • TFIIE
  • TFIIF
  • 1
  • 2

    • (2.4) Cys6

    (2.5) Alternating composition

  • DIDO1
  • GRLF1
  • ING
  • JARID
  • JMJD1B

    • (2.6) WRKY

    (3) Helix-turn-helix domains

    Antennapedia
    ANTP class

    protoHOX
    Hox-like

  • 2
  • Xlox
  • Cdx
  • 2
  • 4
  • extended Hox: Evx1
  • Evx2
  • MEOX1
  • MEOX2
  • Homeobox
  • GBX1
  • GBX2
  • MNX1

    • metaHOX
    NK-like

  • BARHL2
  • BARX1
  • BARX2
  • BSX
  • DBX
  • DLX
  • EMX
  • EN
  • HHEX
  • HLX
  • LBX1
  • LBX2
  • MSX
  • NANOG
  • NKX
  • NATO
  • TLX1
  • TLX2
  • TLX3
  • VAX1
  • VAX2

    • other

  • CRX
  • CUTL1
  • FHL
  • HESX1
  • HOPX
  • LMX
  • NOBOX
  • TALE
  • PHF
  • POU domain
  • SATB2
  • ZEB

    • (3.2) Paired box

  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • PRRX
  • PROP1
  • PHOX
  • RAX
  • SHOX
  • SHOX2
  • VSX1
  • VSX2
  • Bicoid

    • (3.3) Fork head / winged helix

  • 2
  • 3
  • 4
  • 5
  • FOX proteins

    • (3.4) Heat shock factors

  • 2
  • 4

    • (3.5) Tryptophan clusters

    • ELF
  • 4
  • 5
  • EGF
  • ELK
  • ERF
  • ETS
  • ETV
  • FLI1
  • Interferon regulatory factors
  • MYB
  • MYBL2

    • (3.6) TEA domain

    • transcriptional enhancer factor
  • 2
  • 3
  • 4

    • (4) β-Scaffold factors with minor groove contacts

  • NFKB2
  • REL
  • RELA
  • RELB
  • NFAT

    • (4.2) STAT

  • 2
  • 3
  • 4
  • 5
  • 6

    • (4.3) p53-like

  • TP63
  • p73
  • TBX
  • MYRF

    • (4.4) MADS box

  • B
  • C
  • D
  • SRF

    • (4.6) TATA-binding proteins

  • TBPL1

    • (4.7) High-mobility group

  • HMGB
  • HMGN
  • HNF
  • SOX
  • SRY
  • SSRP1
  • TCF/LEF
  • TOX

    • (4.9) Grainyhead

    (4.10) Cold-shock domain

  • YBX1

    • (4.11) Runt

  • CBFA2T3
  • RUNX1
  • RUNX2
  • RUNX3
  • RUNX1T1

    • (0) Other transcription factors

    (0.2) HMGI(Y)

  • 2
  • HBP1

    • (0.3) Pocket domain

  • RBL1
  • RBL2

    • (0.5) AP-2/EREBP-related factors

  • EREBP
  • B3

    • (0.6) Miscellaneous

  • 1B
  • 2
  • 3A
  • 3B
  • 4A
  • CAP
  • IFI
  • MLL
  • MNDA
  • NFY
  • Rho/Sigma

    • see also transcription factor/coregulator deficiencies


    Retrieved from "https://en.wikipedia.org/w/index.php?title=FOXF1&oldid=1079330908"
    Categories: 
    ●Genes on human chromosome 16
     ●Human chromosome 16 gene stubs
     ●Forkhead transcription factors
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