SOX8
Identifiers
SOX8, SRY-box 8, SRY-box transcription factor 8
External IDs
OMIM: 605923; MGI: 98370; HomoloGene: 7950; GeneCards: SOX8; OMA:SOX8 - orthologs
Gene location (Human)
16p13.3
Start
End
Gene location (Mouse)
Chromosome 17 (mouse)[2]
17 A3.3|17 12.69 cM
Start
End
RNA expression pattern
n/a
Molecular function
Cellular component
Biological process
Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search
Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.[5][6][7]
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ATR-16 syndrome).[7]
(1.2) Basic helix-loop-helix (bHLH)
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0.3) Pocket domain
(0.6) Miscellaneous
