TFCP2
Identifiers
TFCP2, LBP1C, LSF, LSF1D, SEF, TFCP2C, transcription factor CP2
External IDs
OMIM: 189889; MGI: 98509; HomoloGene: 4134; GeneCards: TFCP2; OMA:TFCP2 - orthologs
Gene location (Human)
12q13.12-q13.13
Start
End
Gene location (Mouse)
Chromosome 15 (mouse)[2]
15 F1|15 56.33 cM
Start
End
Molecular function
Cellular component
Biological process
Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search
Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.[5][6]
TFCP2 is also called Late SV40 factor (LSF) and it is induced by well-known oncogene AEG-1.[7] LSF also acts as an oncogene in hepatocellular carcinoma.[8] LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).[9]
Along with its main oncogene function in hepatocellular carcinoma (HCC), it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.[8][10] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding with HCC DNA, which results in HCC cell death.[8][10][11]
TFCP2 has been shown to interact with APBB1[12] and RNF2.[13]
(1.2) Basic helix-loop-helix (bHLH)
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0.3) Pocket domain
(0.6) Miscellaneous