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Contents

   



(Top)
  


1 Interactions  




2 References  




3 Further reading  




4 External links  













HES6






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From Wikipedia, the free encyclopedia
  

HES6

Identifiers

Aliases

HES6, C-HAIRY1, HES-6, bHLHb41, bHLHc23, hes family bHLH transcription factor 6

External IDs

OMIM: 610331; MGI: 1859852; HomoloGene: 23111; GeneCards: HES6; OMA:HES6 - orthologs

Gene location (Human)

Chromosome 2 (human)

Chr.

Chromosome 2 (human)[1]

Chromosome 2 (human)

Genomic location for HES6

Genomic location for HES6

Band

2q37.3

Start

238,238,267 bp[1]

End

238,240,662 bp[1]

Gene location (Mouse)

Chromosome 1 (mouse)

Chr.

Chromosome 1 (mouse)[2]

Chromosome 1 (mouse)

Genomic location for HES6

Genomic location for HES6

Band

1|1 D

Start

91,339,205 bp[2]

End

91,341,760 bp[2]

Bgee

Mouse (ortholog)

  • ganglionic eminence

  • ventricular zone

  • secondary oocyte

  • C1 segment

  • mucosa of transverse colon

  • anterior pituitary

  • Brodmann area 9

  • primary visual cortex

  • cingulate gyrus

  • anterior cingulate cortex
    • ventricular zone

  • fossa

  • right kidney

  • internal carotid artery

  • adrenal gland

  • saccule

  • ganglionic eminence

  • left lobe of liver

  • Paneth cell

  • proximal tubule

    • More reference expression data

    BioGPS

    More reference expression data

    Molecular function

  • transcription factor binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • protein dimerization activity
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity
  • transcription coregulator activity
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • transcription corepressor activity
  • sequence-specific DNA binding
  • sequence-specific double-stranded DNA binding

    • Cellular component

  • transcription regulator complex

    • Biological process

  • multicellular organism development
  • cell differentiation
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • nervous system development
  • regulation of transcription, DNA-templated
  • somitogenesis
  • Notch signaling pathway
  • regulation of neurogenesis
  • anterior/posterior pattern specification

    • Sources:Amigo / QuickGO

    Species

    Human

    Mouse

    Entrez

    55502

    55927

    Ensembl

    ENSG00000144485

    ENSMUSG00000067071

    UniProt

    Q96HZ4

    Q9JHE6

    RefSeq (mRNA)

    NM_018645
    NM_001142853
    NM_001282434

    NM_019479
    NM_001360899
    NM_001360900

    RefSeq (protein)

    NP_001136325
    NP_001269363
    NP_061115

    NP_062352
    NP_001347828
    NP_001347829

    Location (UCSC)

    Chr 2: 238.24 – 238.24 Mb

    Chr 1: 91.34 – 91.34 Mb

    PubMed search

    [3]

    [4]

    Wikidata

    Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.[5][6]

    Interactions[edit]

    HES6 has been shown to interact with TLE1.[7]

    References[edit]

    1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144485 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067071 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development. 127 (13): 2933–43. doi:10.1242/dev.127.13.2933. PMID 10851137.
  • ^ "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)".
  • ^ Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.

    • Further reading[edit]

  • Vasiliauskas D, Stern CD (2000). "Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors". Mech. Dev. 98 (1–2): 133–7. doi:10.1016/S0925-4773(00)00443-3. PMID 11044617. S2CID 15528953.
  • Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.
  • Swearingen ML, Sun D, Bourner M, Weinstein EJ (2003). "Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array". Cancer Lett. 198 (2): 229–39. doi:10.1016/S0304-3835(03)00313-6. PMID 12957362.
  • Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S (2003). "Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms". Mol. Cell. Biol. 23 (19): 6922–35. doi:10.1128/MCB.23.19.6922-6935.2003. PMC 193938. PMID 12972610.
  • Kang SA, Seol JH, Kim J (2005). "The conserved WRPW motif of Hes6 mediates proteasomal degradation". Biochem. Biophys. Res. Commun. 332 (1): 33–6. doi:10.1016/j.bbrc.2005.04.089. PMID 15896295.
  • Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F (2007). "HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion". Biochem. Biophys. Res. Commun. 355 (2): 331–7. doi:10.1016/j.bbrc.2007.01.153. PMC 1852427. PMID 17300753.
  • Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D (2007). "Impaired expression of Notch signaling genes in aged human skeletal muscle". J. Gerontol. A Biol. Sci. Med. Sci. 62 (1): 9–17. CiteSeerX 10.1.1.499.7911. doi:10.1093/gerona/62.1.9. PMID 17301032.
  • Scheffer D, Sage C, Corey DP, Pingault V (2007). "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells". FEBS Lett. 581 (24): 4651–6. doi:10.1016/j.febslet.2007.08.059. PMID 17826772. S2CID 13986512.

    • External links[edit]

    (1) Basic domains

    (1.1) Basic leucine zipper (bZIP)

  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • AP-1
  • BACH
  • BATF
  • BLZF1
  • C/EBP
  • CREB
  • CREM
  • DBP
  • DDIT3
  • GABPA
  • GCN4
  • HLF
  • MAF
  • NFE
  • NFIL3
  • NRL
  • NRF
  • XBP1

    • (1.2) Basic helix-loop-helix (bHLH)

    Group A

  • ASCL2
  • ATOH1
  • HAND
  • MESP2
  • Myogenic regulatory factors
  • NeuroD
  • Neurogenins
  • OLIG
  • Paraxis
  • SLC
  • Twist

    • Group B

  • Myc
  • MXD4
  • TCF4

    • Group C
    bHLH-PAS

  • AHRR
  • ARNT
  • CLOCK
  • HIF
  • NPAS
  • PER
  • SIM

    • Group D

    • BHLH
  • 3
  • 9
  • Pho4
  • ID

    • Group E

    • HES
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • HEY

    • Group F
    bHLH-COE

    (1.3) bHLH-ZIP

  • MAX
  • MITF
  • MNT
  • MLX
  • MLXIPL
  • MXI1
  • Myc
  • SREBP
  • USF1

    • (1.4) NF-1

  • B
  • C
  • X
  • SMAD

    • (1.5) RF-X

    • RFX
  • 2
  • 3
  • 4
  • 5
  • 6
  • ANK

    • (1.6) Basic helix-span-helix (bHSH)

  • β
  • γ
  • δ
  • ε

    • (2) Zinc finger DNA-binding domains

    (2.1) Nuclear receptor (Cys4)

    subfamily 1

  • β
  • CAR
  • FXR
  • LXR
  • PPAR
  • PXR
  • RAR
  • ROR
  • Rev-ErbA
  • VDR

    • subfamily 2

  • II
  • Ear-2
  • HNF4
  • PNR
  • RXR
  • Testicular receptor
  • TLX

    • subfamily 3

  • Estrogen
  • Glucocorticoid
  • Mineralocorticoid
  • Progesterone
  • Estrogen related

    • subfamily 4

  • NOR1
  • NURR1

    • subfamily 5

  • SF1

    • subfamily 6

    subfamily 0

  • SHP

    • (2.2) Other Cys4

  • 2
  • 3
  • 4
  • 5
  • 6
  • MTA
  • TRPS1

    • (2.3) Cys2His2

  • TFIIB
  • TFIID
  • TFIIE
  • TFIIF
  • 1
  • 2

    • (2.4) Cys6

    (2.5) Alternating composition

  • DIDO1
  • GRLF1
  • ING
  • JARID
  • JMJD1B

    • (2.6) WRKY

    (3) Helix-turn-helix domains

    Antennapedia
    ANTP class

    protoHOX
    Hox-like

  • 2
  • Xlox
  • Cdx
  • 2
  • 4
  • extended Hox: Evx1
  • Evx2
  • MEOX1
  • MEOX2
  • Homeobox
  • GBX1
  • GBX2
  • MNX1

    • metaHOX
    NK-like

  • BARHL2
  • BARX1
  • BARX2
  • BSX
  • DBX
  • DLX
  • EMX
  • EN
  • HHEX
  • HLX
  • LBX1
  • LBX2
  • MSX
  • NANOG
  • NKX
  • NATO
  • TLX1
  • TLX2
  • TLX3
  • VAX1
  • VAX2

    • other

  • CRX
  • CUTL1
  • FHL
  • HESX1
  • HOPX
  • LMX
  • NOBOX
  • TALE
  • PHF
  • POU domain
  • SATB2
  • ZEB

    • (3.2) Paired box

  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • PRRX
  • PROP1
  • PHOX
  • RAX
  • SHOX
  • SHOX2
  • VSX1
  • VSX2
  • Bicoid

    • (3.3) Fork head / winged helix

  • 2
  • 3
  • 4
  • 5
  • FOX proteins

    • (3.4) Heat shock factors

  • 2
  • 4

    • (3.5) Tryptophan clusters

    • ELF
  • 4
  • 5
  • EGF
  • ELK
  • ERF
  • ETS
  • ETV
  • FLI1
  • Interferon regulatory factors
  • MYB
  • MYBL2

    • (3.6) TEA domain

    • transcriptional enhancer factor
  • 2
  • 3
  • 4

    • (4) β-Scaffold factors with minor groove contacts

  • NFKB2
  • REL
  • RELA
  • RELB
  • NFAT

    • (4.2) STAT

  • 2
  • 3
  • 4
  • 5
  • 6

    • (4.3) p53-like

  • TP63
  • p73
  • TBX
  • MYRF

    • (4.4) MADS box

  • B
  • C
  • D
  • SRF

    • (4.6) TATA-binding proteins

  • TBPL1

    • (4.7) High-mobility group

  • HMGB
  • HMGN
  • HNF
  • SOX
  • SRY
  • SSRP1
  • TCF/LEF
  • TOX

    • (4.9) Grainyhead

    (4.10) Cold-shock domain

  • YBX1

    • (4.11) Runt

  • CBFA2T3
  • RUNX1
  • RUNX2
  • RUNX3
  • RUNX1T1

    • (0) Other transcription factors

    (0.2) HMGI(Y)

  • 2
  • HBP1

    • (0.3) Pocket domain

  • RBL1
  • RBL2

    • (0.5) AP-2/EREBP-related factors

  • EREBP
  • B3

    • (0.6) Miscellaneous

  • 1B
  • 2
  • 3A
  • 3B
  • 4A
  • CAP
  • IFI
  • MLL
  • MNDA
  • NFY
  • Rho/Sigma

    • see also transcription factor/coregulator deficiencies

    This article incorporates text from the United States National Library of Medicine, which is in the public domain.


    Stub icon

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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=HES6&oldid=1080157514"
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     ●Human chromosome 2 gene stubs
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    ●This page was last edited on 30 March 2022, at 16:28 (UTC).
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