Jump to content
 







Main menu
    


Navigation  


●Main page
 ●Contents
 ●Current events
 ●Random article
 ●About Wikipedia
 ●Contact us
 ●Donate
  



Contribute  


●Help
 ●Learn to edit
 ●Community portal
 ●Recent changes
 ●Upload file
  







Search  

































●Create account

●Log in
 









●Create account
 ● Log in
  



Pages for logged out editors learn more  


●Contributions
 ●Talk
  


















Contents

   



(Top)
  


1 References  




2 Further reading  




3 External links  













HIC2






●العربية
 ●Español
 ●مصرى
 ●Татарча / tatarça
 ●Українська
  
Edit links
  








●Article
 ●Talk
  
















●Read
 ●Edit
 ●View history
  







Tools
    


Actions  


●Read
 ●Edit
 ●View history
  



General  


●What links here
 ●Related changes
 ●Upload file
 ●Special pages
 ●Permanent link
 ●Page information
 ●Cite this page
 ●Get shortened URL
 ●Download QR code
 ●Wikidata item
  



Print/export  


●Download as PDF
 ●Printable version
  















Appearance
    

 





From Wikipedia, the free encyclopedia
  

HIC2

Identifiers

Aliases

HIC2, HRG22, ZBTB30, ZNF907, hypermethylated in cancer 2, HIC ZBTB transcriptional repressor 2

External IDs

OMIM: 607712; MGI: 1929869; HomoloGene: 9020; GeneCards: HIC2; OMA:HIC2 - orthologs

Gene location (Human)

Chromosome 22 (human)

Chr.

Chromosome 22 (human)[1]

Chromosome 22 (human)

Genomic location for HIC2

Genomic location for HIC2

Band

22q11.21

Start

21,417,371 bp[1]

End

21,451,463 bp[1]

Gene location (Mouse)

Chromosome 16 (mouse)

Chr.

Chromosome 16 (mouse)[2]

Chromosome 16 (mouse)

Genomic location for HIC2

Genomic location for HIC2

Band

16|16 A3

Start

17,051,436 bp[2]

End

17,081,294 bp[2]

Bgee

Mouse (ortholog)

  • secondary oocyte

  • amniotic fluid

  • endothelial cell

  • placenta

  • gonad

  • vena cava

  • Brodmann area 23

  • parotid gland

  • Region I of hippocampus proper

  • gingival epithelium
    • zygote

  • secondary oocyte

  • yolk sac

  • female urethra

  • blastocyst

  • abdominal wall

  • mandibular prominence

  • maxillary prominence

  • primitive streak

  • epiblast

    • More reference expression data

    BioGPS





    More reference expression data

    Molecular function

  • protein C-terminus binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific

    • Cellular component

    Biological process

  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
  • negative regulation of transcription by RNA polymerase II

    • Sources:Amigo / QuickGO

    Species

    Human

    Mouse

    Entrez

    23119

    58180

    Ensembl

    ENSG00000169635

    ENSMUSG00000050240

    UniProt

    Q96JB3

    Q9JLZ6

    RefSeq (mRNA)

    NM_015094

    NM_178922

    RefSeq (protein)

    NP_055909

    NP_849253

    Location (UCSC)

    Chr 22: 21.42 – 21.45 Mb

    Chr 16: 17.05 – 17.08 Mb

    PubMed search

    [3]

    [4]

    Wikidata

    Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.[5][6]


    References[edit]

    1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169635 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050240 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ Deltour S, Pinte S, Guerardel C, Leprince D (Sep 2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem Biophys Res Commun. 287 (2): 427–34. doi:10.1006/bbrc.2001.5624. PMID 11554746.
  • ^ "Entrez Gene: HIC2 hypermethylated in cancer 2".

    • Further reading[edit]

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Young TM, Wang Q, Pe'ery T, Mathews MB (2003). "The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription". Mol. Cell. Biol. 23 (18): 6373–84. doi:10.1128/MCB.23.18.6373-6384.2003. PMC 193714. PMID 12944466.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deltour S, Pinte S, Guerardel C, et al. (2002). "The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif". Mol. Cell. Biol. 22 (13): 4890–901. doi:10.1128/MCB.22.13.4890-4901.2002. PMC 133903. PMID 12052894.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

    • External links[edit]

    This article incorporates text from the United States National Library of Medicine, which is in the public domain.

    (1) Basic domains

    (1.1) Basic leucine zipper (bZIP)

  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • AP-1
  • BACH
  • BATF
  • BLZF1
  • C/EBP
  • CREB
  • CREM
  • DBP
  • DDIT3
  • GABPA
  • GCN4
  • HLF
  • MAF
  • NFE
  • NFIL3
  • NRL
  • NRF
  • XBP1

    • (1.2) Basic helix-loop-helix (bHLH)

    Group A

  • ASCL2
  • ATOH1
  • HAND
  • MESP2
  • Myogenic regulatory factors
  • NeuroD
  • Neurogenins
  • OLIG
  • Paraxis
  • SLC
  • Twist

    • Group B

  • Myc
  • MXD4
  • TCF4

    • Group C
    bHLH-PAS

  • AHRR
  • ARNT
  • CLOCK
  • HIF
  • NPAS
  • PER
  • SIM

    • Group D

    • BHLH
  • 3
  • 9
  • Pho4
  • ID

    • Group E

    • HES
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • HEY

    • Group F
    bHLH-COE

    (1.3) bHLH-ZIP

  • MAX
  • MITF
  • MNT
  • MLX
  • MLXIPL
  • MXI1
  • Myc
  • SREBP
  • USF1

    • (1.4) NF-1

  • B
  • C
  • X
  • SMAD

    • (1.5) RF-X

    • RFX
  • 2
  • 3
  • 4
  • 5
  • 6
  • ANK

    • (1.6) Basic helix-span-helix (bHSH)

  • β
  • γ
  • δ
  • ε

    • (2) Zinc finger DNA-binding domains

    (2.1) Nuclear receptor (Cys4)

    subfamily 1

  • β
  • CAR
  • FXR
  • LXR
  • PPAR
  • PXR
  • RAR
  • ROR
  • Rev-ErbA
  • VDR

    • subfamily 2

  • II
  • Ear-2
  • HNF4
  • PNR
  • RXR
  • Testicular receptor
  • TLX

    • subfamily 3

  • Estrogen
  • Glucocorticoid
  • Mineralocorticoid
  • Progesterone
  • Estrogen related

    • subfamily 4

  • NOR1
  • NURR1

    • subfamily 5

  • SF1

    • subfamily 6

    subfamily 0

  • SHP

    • (2.2) Other Cys4

  • 2
  • 3
  • 4
  • 5
  • 6
  • MTA
  • TRPS1

    • (2.3) Cys2His2

  • TFIIB
  • TFIID
  • TFIIE
  • TFIIF
  • 1
  • 2

    • (2.4) Cys6

    (2.5) Alternating composition

  • DIDO1
  • GRLF1
  • ING
  • JARID
  • JMJD1B

    • (2.6) WRKY

    (3) Helix-turn-helix domains

    Antennapedia
    ANTP class

    protoHOX
    Hox-like

  • 2
  • Xlox
  • Cdx
  • 2
  • 4
  • extended Hox: Evx1
  • Evx2
  • MEOX1
  • MEOX2
  • Homeobox
  • GBX1
  • GBX2
  • MNX1

    • metaHOX
    NK-like

  • BARHL2
  • BARX1
  • BARX2
  • BSX
  • DBX
  • DLX
  • EMX
  • EN
  • HHEX
  • HLX
  • LBX1
  • LBX2
  • MSX
  • NANOG
  • NKX
  • NATO
  • TLX1
  • TLX2
  • TLX3
  • VAX1
  • VAX2

    • other

  • CRX
  • CUTL1
  • FHL
  • HESX1
  • HOPX
  • LMX
  • NOBOX
  • TALE
  • PHF
  • POU domain
  • SATB2
  • ZEB

    • (3.2) Paired box

  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • PRRX
  • PROP1
  • PHOX
  • RAX
  • SHOX
  • SHOX2
  • VSX1
  • VSX2
  • Bicoid

    • (3.3) Fork head / winged helix

  • 2
  • 3
  • 4
  • 5
  • FOX proteins

    • (3.4) Heat shock factors

  • 2
  • 4

    • (3.5) Tryptophan clusters

    • ELF
  • 4
  • 5
  • EGF
  • ELK
  • ERF
  • ETS
  • ETV
  • FLI1
  • Interferon regulatory factors
  • MYB
  • MYBL2

    • (3.6) TEA domain

    • transcriptional enhancer factor
  • 2
  • 3
  • 4

    • (4) β-Scaffold factors with minor groove contacts

  • NFKB2
  • REL
  • RELA
  • RELB
  • NFAT

    • (4.2) STAT

  • 2
  • 3
  • 4
  • 5
  • 6

    • (4.3) p53-like

  • TP63
  • p73
  • TBX
  • MYRF

    • (4.4) MADS box

  • B
  • C
  • D
  • SRF

    • (4.6) TATA-binding proteins

  • TBPL1

    • (4.7) High-mobility group

  • HMGB
  • HMGN
  • HNF
  • SOX
  • SRY
  • SSRP1
  • TCF/LEF
  • TOX

    • (4.9) Grainyhead

    (4.10) Cold-shock domain

  • YBX1

    • (4.11) Runt

  • CBFA2T3
  • RUNX1
  • RUNX2
  • RUNX3
  • RUNX1T1

    • (0) Other transcription factors

    (0.2) HMGI(Y)

  • 2
  • HBP1

    • (0.3) Pocket domain

  • RBL1
  • RBL2

    • (0.5) AP-2/EREBP-related factors

  • EREBP
  • B3

    • (0.6) Miscellaneous

  • 1B
  • 2
  • 3A
  • 3B
  • 4A
  • CAP
  • IFI
  • MLL
  • MNDA
  • NFY
  • Rho/Sigma

    • see also transcription factor/coregulator deficiencies


    Stub icon

    This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

  • t
  • e

    • Retrieved from "https://en.wikipedia.org/w/index.php?title=HIC2&oldid=1188025255"
    Categories: 
    ●Genes on human chromosome 22
     ●Transcription factors
     ●Human chromosome 22 gene stubs
     Hidden categories: 
    ●Articles with short description
     ●Short description matches Wikidata
     ●Wikipedia articles incorporating text from the United States National Library of Medicine
     ●All stub articles
      


    ●This page was last edited on 2 December 2023, at 22:41 (UTC).
    ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.


    ●Privacy policy
    ●About Wikipedia
    ●Disclaimers
    ●Contact Wikipedia
    ●Code of Conduct
    ●Developers
    ●Statistics
    ●Cookie statement
    ●Mobile view


    Wikimedia Foundation
    Powered by MediaWiki