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Contents

   



(Top)
  


1 References  




2 Further reading  




3 External links  













SIX5






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From Wikipedia, the free encyclopedia
  

SIX5

Identifiers

Aliases

SIX5, BOR2, DMAHP, SIX homeobox 5

External IDs

OMIM: 600963; MGI: 106220; HomoloGene: 72248; GeneCards: SIX5; OMA:SIX5 - orthologs

Gene location (Human)

Chromosome 19 (human)

Chr.

Chromosome 19 (human)[1]

Chromosome 19 (human)

Genomic location for SIX5

Genomic location for SIX5

Band

19q13.32

Start

45,764,785 bp[1]

End

45,769,252 bp[1]

Gene location (Mouse)

Chromosome 7 (mouse)

Chr.

Chromosome 7 (mouse)[2]

Chromosome 7 (mouse)

Genomic location for SIX5

Genomic location for SIX5

Band

7 A3|7 9.46 cM

Start

18,828,519 bp[2]

End

18,832,474 bp[2]

Bgee

Mouse (ortholog)

  • cardiac muscle tissue of right atrium

  • right uterine tube

  • right ovary

  • myocardium of left ventricle

  • left ovary

  • parotid gland

  • canal of the cervix

  • right coronary artery

  • left uterine tube

  • body of uterus
    • ascending aorta

  • genital tubercle

  • aortic valve

  • corneal stroma

  • tail of embryo

  • cardiac muscle tissue of left ventricle

  • ventricular zone

  • molar

  • Gonadal ridge

  • male urethra

    • More reference expression data

    BioGPS

    n/a

    Molecular function

  • DNA binding
  • sequence-specific DNA binding
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • transcription cis-regulatory region binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific

    • Cellular component

  • cytoplasm
  • transcription regulator complex

    • Biological process

  • negative regulation of cell population proliferation
  • lens development in camera-type eye
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • spermatid development
  • negative regulation of skeletal muscle satellite cell proliferation
  • anatomical structure development

    • Sources:Amigo / QuickGO

    Species

    Human

    Mouse

    Entrez

    147912

    20475

    Ensembl

    ENSG00000177045

    ENSMUSG00000040841

    UniProt

    Q8N196

    P70178

    RefSeq (mRNA)

    NM_175875

    NM_011383

    RefSeq (protein)

    NP_787071

    NP_035513

    Location (UCSC)

    Chr 19: 45.76 – 45.77 Mb

    Chr 7: 18.83 – 18.83 Mb

    PubMed search

    [3]

    [4]

    Wikidata

    Homeobox protein SIX5 is a protein that in humans is encoded by the SIX5 gene.[5][6]

    References[edit]

    1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177045 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040841 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ Boucher CA, King SK, Carey N, Krahe R, Winchester CL, Rahman S, Creavin T, Meghji P, Bailey ME, Chartier FL (Apr 1996). "A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat". Hum Mol Genet. 4 (10): 1919–25. doi:10.1093/hmg/4.10.1919. PMID 8595416.
  • ^ "Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila)".

    • Further reading[edit]

  • Winchester CL, Ferrier RK, Sermoni A, Clark BJ, Johnson KJ (1999). "Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy". Hum. Mol. Genet. 8 (3): 481–92. doi:10.1093/hmg/8.3.481. PMID 9949207.
  • Ohto H, Kamada S, Tago K, Tominaga SI, Ozaki H, Sato S, Kawakami K (2000). "Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya". Mol. Cell. Biol. 19 (10): 6815–24. doi:10.1128/mcb.19.10.6815. PMC 84678. PMID 10490620.
  • Harris SE, Winchester CL, Johnson KJ (2000). "Functional analysis of the homeodomain protein SIX5". Nucleic Acids Res. 28 (9): 1871–8. doi:10.1093/nar/28.9.1871. PMC 103302. PMID 10756185.
  • Winchester C, Robertson S, MacLeod T, Johnson K, Thomas M (2000). "Expression of a homeobox gene (SIX5) in borderline ovarian tumours". J. Clin. Pathol. 53 (3): 212–7. doi:10.1136/jcp.53.3.212. PMC 1731149. PMID 10823141.
  • Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. hdl:10261/112516. PMID 11748221.
  • Sato S, Nakamura M, Cho DH, Tapscott SJ, Ozaki H, Kawakami K (2002). "Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1". Hum. Mol. Genet. 11 (9): 1045–58. doi:10.1093/hmg/11.9.1045. PMID 11978764.
  • Fougerousse F, Durand M, Lopez S, Suel L, Demignon J, Thornton C, Ozaki H, Kawakami K, Barbet P, Beckmann JS, Maire P (2003). "Six and Eya expression during human somitogenesis and MyoD gene family activation". J. Muscle Res. Cell. Motil. 23 (3): 255–64. doi:10.1023/A:1020990825644. PMID 12500905. S2CID 42497614.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Hoskins BE, Cramer CH, Silvius D, Zou D, Raymond RM, Orten DJ, Kimberling WJ, Smith RJ, Weil D, Petit C, Otto EA, Xu PX, Hildebrandt F (2007). "Transcription Factor SIX5 Is Mutated in Patients with Branchio-Oto-Renal Syndrome". Am. J. Hum. Genet. 80 (4): 800–4. doi:10.1086/513322. PMC 1852719. PMID 17357085.

    • External links[edit]

    (1) Basic domains

    (1.1) Basic leucine zipper (bZIP)

  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • AP-1
  • BACH
  • BATF
  • BLZF1
  • C/EBP
  • CREB
  • CREM
  • DBP
  • DDIT3
  • GABPA
  • GCN4
  • HLF
  • MAF
  • NFE
  • NFIL3
  • NRL
  • NRF
  • XBP1

    • (1.2) Basic helix-loop-helix (bHLH)

    Group A

  • ASCL2
  • ATOH1
  • HAND
  • MESP2
  • Myogenic regulatory factors
  • NeuroD
  • Neurogenins
  • OLIG
  • Paraxis
  • SLC
  • Twist

    • Group B

  • Myc
  • MXD4
  • TCF4

    • Group C
    bHLH-PAS

  • AHRR
  • ARNT
  • CLOCK
  • HIF
  • NPAS
  • PER
  • SIM

    • Group D

    • BHLH
  • 3
  • 9
  • Pho4
  • ID

    • Group E

    • HES
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • HEY

    • Group F
    bHLH-COE

    (1.3) bHLH-ZIP

  • MAX
  • MITF
  • MNT
  • MLX
  • MLXIPL
  • MXI1
  • Myc
  • SREBP
  • USF1

    • (1.4) NF-1

  • B
  • C
  • X
  • SMAD

    • (1.5) RF-X

    • RFX
  • 2
  • 3
  • 4
  • 5
  • 6
  • ANK

    • (1.6) Basic helix-span-helix (bHSH)

  • β
  • γ
  • δ
  • ε

    • (2) Zinc finger DNA-binding domains

    (2.1) Nuclear receptor (Cys4)

    subfamily 1

  • β
  • CAR
  • FXR
  • LXR
  • PPAR
  • PXR
  • RAR
  • ROR
  • Rev-ErbA
  • VDR

    • subfamily 2

  • II
  • Ear-2
  • HNF4
  • PNR
  • RXR
  • Testicular receptor
  • TLX

    • subfamily 3

  • Estrogen
  • Glucocorticoid
  • Mineralocorticoid
  • Progesterone
  • Estrogen related

    • subfamily 4

  • NOR1
  • NURR1

    • subfamily 5

  • SF1

    • subfamily 6

    subfamily 0

  • SHP

    • (2.2) Other Cys4

  • 2
  • 3
  • 4
  • 5
  • 6
  • MTA
  • TRPS1

    • (2.3) Cys2His2

  • TFIIB
  • TFIID
  • TFIIE
  • TFIIF
  • 1
  • 2

    • (2.4) Cys6

    (2.5) Alternating composition

  • DIDO1
  • GRLF1
  • ING
  • JARID
  • JMJD1B

    • (2.6) WRKY

    (3) Helix-turn-helix domains

    Antennapedia
    ANTP class

    protoHOX
    Hox-like

  • 2
  • Xlox
  • Cdx
  • 2
  • 4
  • extended Hox: Evx1
  • Evx2
  • MEOX1
  • MEOX2
  • Homeobox
  • GBX1
  • GBX2
  • MNX1

    • metaHOX
    NK-like

  • BARHL2
  • BARX1
  • BARX2
  • BSX
  • DBX
  • DLX
  • EMX
  • EN
  • HHEX
  • HLX
  • LBX1
  • LBX2
  • MSX
  • NANOG
  • NKX
  • NATO
  • TLX1
  • TLX2
  • TLX3
  • VAX1
  • VAX2

    • other

  • CRX
  • CUTL1
  • FHL
  • HESX1
  • HOPX
  • LMX
  • NOBOX
  • TALE
  • PHF
  • POU domain
  • SATB2
  • ZEB

    • (3.2) Paired box

  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • PRRX
  • PROP1
  • PHOX
  • RAX
  • SHOX
  • SHOX2
  • VSX1
  • VSX2
  • Bicoid

    • (3.3) Fork head / winged helix

  • 2
  • 3
  • 4
  • 5
  • FOX proteins

    • (3.4) Heat shock factors

  • 2
  • 4

    • (3.5) Tryptophan clusters

    • ELF
  • 4
  • 5
  • EGF
  • ELK
  • ERF
  • ETS
  • ETV
  • FLI1
  • Interferon regulatory factors
  • MYB
  • MYBL2

    • (3.6) TEA domain

    • transcriptional enhancer factor
  • 2
  • 3
  • 4

    • (4) β-Scaffold factors with minor groove contacts

  • NFKB2
  • REL
  • RELA
  • RELB
  • NFAT

    • (4.2) STAT

  • 2
  • 3
  • 4
  • 5
  • 6

    • (4.3) p53-like

  • TP63
  • p73
  • TBX
  • MYRF

    • (4.4) MADS box

  • B
  • C
  • D
  • SRF

    • (4.6) TATA-binding proteins

  • TBPL1

    • (4.7) High-mobility group

  • HMGB
  • HMGN
  • HNF
  • SOX
  • SRY
  • SSRP1
  • TCF/LEF
  • TOX

    • (4.9) Grainyhead

    (4.10) Cold-shock domain

  • YBX1

    • (4.11) Runt

  • CBFA2T3
  • RUNX1
  • RUNX2
  • RUNX3
  • RUNX1T1

    • (0) Other transcription factors

    (0.2) HMGI(Y)

  • 2
  • HBP1

    • (0.3) Pocket domain

  • RBL1
  • RBL2

    • (0.5) AP-2/EREBP-related factors

  • EREBP
  • B3

    • (0.6) Miscellaneous

  • 1B
  • 2
  • 3A
  • 3B
  • 4A
  • CAP
  • IFI
  • MLL
  • MNDA
  • NFY
  • Rho/Sigma

    • see also transcription factor/coregulator deficiencies


    Stub icon

    This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=SIX5&oldid=1193606182"
    Categories: 
    ●Genes on human chromosome 19
     ●Transcription factors
     ●Human chromosome 19 gene stubs
     Hidden categories: 
    ●Articles with short description
     ●Short description matches Wikidata
     ●All stub articles
      


    ●This page was last edited on 4 January 2024, at 17:51 (UTC).
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