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(Top) 1 Function 2 References 3 Further reading

NFIL3

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NFIL3

Identifiers

Aliases

NFIL3, E4BP4, IL3BP1, NF-IL3A, NFIL3A, nuclear factor, interleukin 3 regulated

External IDs

OMIM: 605327; MGI: 109495; HomoloGene: 3928; GeneCards: NFIL3; OMA:NFIL3 - orthologs

Gene location (Human)

Chr.

Chromosome 9 (human)^[1]

Band

9q22.31

Start

91,409,045 bp^[1]

End

91,423,832 bp^[1]

Gene location (Mouse)

Chr.

Chromosome 13 (mouse)^[2]

Band

13 B1|13 27.68 cM

Start

53,121,245 bp^[2]

End

53,135,109 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

vena cava

pericardium

gastric mucosa

left uterine tube

cartilage tissue

popliteal artery

tibial arteries

stromal cell of endometrium

periodontal fiber

right ventricle

Top expressed in

muscle of thigh

gastrula

granulocyte

zygote

primary oocyte

secondary oocyte

digastric muscle

left lobe of liver

plantaris muscle

sternocleidomastoid muscle

More reference expression data

BioGPS

More reference expression data

Gene ontology

Molecular function

DNA-binding transcription factor activity

DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

RNA polymerase II transcription regulatory region sequence-specific DNA binding

protein binding

transcription corepressor activity

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

identical protein binding

Cellular component

nucleus

Biological process

cellular response to interleukin-4

positive regulation of gene expression

regulation of transcription, DNA-templated

negative regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

circadian rhythm

immune response

transcription, DNA-templated

rhythmic process

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

NM_005384
NM_001289999
NM_001290000

NM_017373

RefSeq (protein)

NP_001276928
NP_001276929
NP_005375

NP_059069

Location (UCSC)

Chr 9: 91.41 – 91.42 Mb

Chr 13: 53.12 – 53.14 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Nuclear factor, interleukin 3 regulated, also known as NFIL3orE4BP4 is a protein which in humans is encoded by the NFIL3 gene.^[5]

Function[edit]

Expression of interleukin-3 (IL-3) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.^[5]^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165030 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056749 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ ^a ^b "Entrez Gene: NFIL3 nuclear factor, interleukin 3 regulated".

^ Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD (November 1995). "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter". Molecular and Cellular Biology. 15 (11): 6055–63. doi:10.1128/mcb.15.11.6055. PMC 230857. PMID 7565758.

Further reading[edit]

Cowell IG, Skinner A, Hurst HC (July 1992). "Transcriptional repression by a novel member of the bZIP family of transcription factors". Molecular and Cellular Biology. 12 (7): 3070–7. doi:10.1128/mcb.12.7.3070. PMC 364521. PMID 1620116.

Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD (November 1995). "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter". Molecular and Cellular Biology. 15 (11): 6055–63. doi:10.1128/mcb.15.11.6055. PMC 230857. PMID 7565758.

Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (September 1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.

Cowell IG, Hurst HC (September 1996). "Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1". Nucleic Acids Research. 24 (18): 3607–13. doi:10.1093/nar/24.18.3607. PMC 146135. PMID 8836190.

Ikushima S, Inukai T, Inaba T, Nimer SD, Cleveland JL, Look AT (March 1997). "Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (6): 2609–14. Bibcode:1997PNAS...94.2609I. doi:10.1073/pnas.94.6.2609. PMC 20136. PMID 9122243.

Hulme DJ, Blair IP, Dawkins JL, Nicholson GA (June 2000). "Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis". Human Genetics. 106 (6): 594–6. doi:10.1007/s004390000306. PMID 10942106.

Ozkurt IC, Tetradis S (July 2003). "Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts". The Journal of Biological Chemistry. 278 (29): 26803–9. doi:10.1074/jbc.M212652200. PMID 12743120.