Contents

Marbofloxacin

Chemical compound

Marbofloxacin

Clinical data
Trade names	XeniQuin bolus & Injection (Opsonin Agrovet BD)
AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth
ATCvet code	QJ01MA93 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers
IUPAC name 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol(3,2,1-ij)(4,2,1)benzoxadiazin-6 carboxylic acid
CAS Number	115550-35-1 N
ChemSpider	54663 Y
UNII	8X09WU898T
ChEMBL	ChEMBL478120 Y
CompTox Dashboard (EPA)	DTXSID4046600
ECHA InfoCard	100.168.181
Chemical and physical data
Formula	C17H19FN4O4
Molar mass	362.361 g·mol−1
3D model (JSmol)	Interactive image
SMILES Fc4cc1c2N(/C=C(\C1=O)C(=O)O)N(COc2c4N3CCN(C)CC3)C
InChI InChI=1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25) Y Key:BPFYOAJNDMUVBL-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Marbofloxacin is a carboxylic acid derivative third generation fluoroquinolone antibiotic. It is used in veterinary medicine under the brand names Marbocyl, Forcyl, Marbo vet and Zeniquin. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name Aurizon (CAS number 115550-35-1).

Mechanism of action[edit]

Its mechanism of action is not thoroughly understood, but it is believed to be similar to the other fluoroquinolones by impairing the bacterial DNA gyrase which results in rapid bactericidal activity.^[1] The other proposed mechanisms include that it acts against nondividing bacteria and does not require protein and RNA synthesis, which block protein and RNA synthesis respectively.^{[2][clarification needed]}

Activity[edit]

Marbofloxacin is a synthetic, broad spectrum bactericidal agent. The bactericidal activity of marbofloxacin is concentration dependent, with susceptible bacteria cell death occurring within 20–30 minutes of exposure. Like other fluoroquinolones, marbofloxacin has demonstrated a significant post-antibiotic effect for both gram– and + bacteria and is active in both stationary and growth phases of bacterial replication.^[3]

It has good activity against many gram-negative bacilli and cocci, is effective against:

Application[edit]

Marbofloxacin can be used both orally and topically. It is particularly used for infections of the skin, respiratory system and mammary glands in dogs and cats, as well as with urinary tract infections. For dogs, a dose ranges from 2.75 - 5.5 mg/kg once a day. The duration of treatment is usually at least five days, longer if there is a concurrent fungal or yeast infection.^[4] Maximum duration of treatment is 30 days.^[3]

Contraindications and side effects[edit]

Marbofloxacin should usually be avoided in young animals because of potential cartilage abnormalities. In rare occasion, it can cause central nervous system (CNS) stimulation and should be used with caution in patients with seizure disorders.^[3] Under certain conditions it can cause discomfort such as cramps, treatable with diazepam. Other adverse effects are usually limited to gastrointestinal tract (GI) distress (vomiting, anorexia, soft stools, diarrhoea) and decreased activity.^[3]

References[edit]