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1 See also  





2 References  














Oxolinic acid






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From Wikipedia, the free encyclopedia
 


Oxolinic acid
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 5-Ethyl-8-oxo-5,8-dihydro[1,3]dioxolo[4,5-g]quinoline- 7-carboxylic acid

CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.035.213 Edit this at Wikidata
Chemical and physical data
FormulaC13H11NO5
Molar mass261.233 g·mol−1
3D model (JSmol)
  • CCN1C=C(C(=O)C2=CC3=C(C=C21)OCO3)C(=O)O

  • InChI=1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17) ☒N

  • Key:KYGZCKSPAKDVKC-UHFFFAOYSA-N ☒N

 ☒NcheckY (what is this?)  (verify)

Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s.[1][2] Dosages 12–20 mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.[3]

See also[edit]

References[edit]

  1. ^ JP Patent 49138244
  • ^ Gleckman R, Alvarez S, Joubert DW, Matthews SJ (August 1979). "Drug therapy reviews: oxolinic acid". American Journal of Hospital Pharmacy. 36 (8): 1077–9. PMID 384788.
  • ^ Garcia de Mateos-Verchere J, Vaugeois JM, Naudin B, Costentin J (December 1998). "Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor". European Neuropsychopharmacology. 8 (4): 255–9. doi:10.1016/S0924-977X(97)00083-7. PMID 9928913. S2CID 22626555.


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  • Retrieved from "https://en.wikipedia.org/w/index.php?title=Oxolinic_acid&oldid=1190909844"

    Categories: 
    Quinolone antibiotics
    Dopamine reuptake inhibitors
    Carboxylic acids
    Nitrogen heterocycles
    Oxygen heterocycles
    Heterocyclic compounds with 3 rings
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    This page was last edited on 20 December 2023, at 15:34 (UTC).

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