CD151 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | CD151, GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24, CD151 molecule (Raph blood group), EBS7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602243; MGI: 1096360; HomoloGene: 20916; GeneCards: CD151; OMA:CD151 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.[5]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.[5] Abnormalities in CD151 have been implicated in a form of epidermolysis bullosa.[6][7]
CD151 has been shown to interact with CD46.[8]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Arrestin |
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Membrane-spanning 4A |
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Myelin |
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Pulmonary surfactant |
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Tetraspanin |
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Other/ungrouped |
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