EIF1AX | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | EIF1AX, EIF1A, EIF1AP1, EIF4C, eIF-1A, eIF-4C, eukaryotic translation initiation factor 1A, X-linked, eukaryotic translation initiation factor 1A X-linked | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 300186; MGI: 95298; HomoloGene: 20364; GeneCards: EIF1AX; OMA:EIF1AX - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene.[5][6][7] This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs.[7]
eIF1A is a small protein (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal A-site, in a manner similar to the functionally related bacterial counterpart IF1.[8]
Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3.[9] eIF1A is mutated in thyroid cancers.[10]
EIF1AX has been shown to interact with IPO13.[11]
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Proteins |
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Other concepts |
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This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it. |