39S ribosomal protein L12, mitochondrial is a protein that in humans is encoded by the MRPL12 gene.[4][5][6]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% proteintorRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex.[6]
PDB gallery
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2ftc: Structural Model for the Large Subunit of the Mammalian Mitochondrial Ribosome
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Ribosomal RNA / ribosome subunits
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Ribosomal proteins | (See article table) |
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