Contents

MRPS16

Protein-coding gene in the species Homo sapiens

MRPS16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS16, COXPD2, MRP-S16, RPMS16, CGI-132, mitochondrial ribosomal protein S16
External IDs	OMIM: 609204; MGI: 1913492; HomoloGene: 9370; GeneCards: MRPS16; OMA:MRPS16 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.2 Start 73,248,843 bp[1] End 73,252,693 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 20,439,372 bp[2] End 20,443,702 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right adrenal gland gastrocnemius muscle right adrenal cortex left adrenal gland left adrenal cortex muscle of thigh left ventricle rectum right auricle Top expressed in digastric muscle temporal muscle sternocleidomastoid muscle extraocular muscle cardiac muscles myocardium of ventricle triceps brachii muscle calvaria brown adipose tissue intercostal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding Cellular component mitochondrial inner membrane ribosome intracellular anatomical structure mitochondrion mitochondrial small ribosomal subunit cytosol Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51021 66242 Ensembl ENSG00000182180 ENSMUSG00000049960 UniProt Q9Y3D3 Q9CPX7 RefSeq (mRNA) NM_016065 NM_025440 RefSeq (protein) NP_057149 NP_079716 Location (UCSC) Chr 10: 73.25 – 73.25 Mb Chr 14: 20.44 – 20.44 Mb PubMed search [3] [4]
Wikidata
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28S ribosomal protein S16, mitochondrial is a protein that in humans is encoded by the MRPS16 gene.^[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% proteintorRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described.^[6]

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Further reading[edit]

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