Contents

60S ribosomal protein L15

Protein found in humans

RPL15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J7R, 4V5Z, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC,%%s3J7R, 4V5Z, 4V6X, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 5AJ0, 3J7Q, 4UG0, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL15, DBA12, EC45, L15, RPL10, RPLY10, RPYL10, ribosomal protein L15
External IDs	OMIM: 604174; MGI: 1913730; HomoloGene: 37713; GeneCards: RPL15; OMA:RPL15 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p24.2 Start 23,916,591 bp[1] End 23,924,374 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 A1|14 Start 4,198,305 bp[2] End 4,201,873 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary left testis right testis right ovary germinal epithelium middle temporal gyrus gonad gallbladder canal of the cervix caput epididymis Top expressed in embryo ventricular zone embryo morula blastocyst epiblast yolk sac primitive streak lip Gonadal ridge More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding structural constituent of ribosome cadherin binding RNA binding Cellular component cytosol ribosome membrane intracellular anatomical structure extracellular exosome nucleus cytosolic large ribosomal subunit A band Biological process cytoplasmic translation protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing response to ethanol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6138 66480 Ensembl ENSG00000174748 ENSMUSG00000012405 UniProt P61313 Q9CZM2 RefSeq (mRNA) NM_001253379 NM_001253380 NM_001253382 NM_001253383 NM_001253384 NM_002948 NM_025586 NM_001359897 NM_001359899 RefSeq (protein) NP_001240308 NP_001240309 NP_001240311 NP_001240312 NP_001240313 NP_002939 NP_001240308.1 NP_001240309.1 NP_001240311.1 NP_001240312.1 NP_002939.2 NP_079862 NP_001346826 NP_001346828 Location (UCSC) Chr 3: 23.92 – 23.92 Mb Chr 14: 4.2 – 4.2 Mb PubMed search [3] [4]
Wikidata
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60S ribosomal protein L15 is a protein that in humans is encoded by the RPL15 gene.^[5][6]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]

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