Contents

60S ribosomal protein L29

Protein found in humans

RPL29
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL29, HIP, HUML29, RPL29P10, RPL29_3_370, ribosomal protein L29
External IDs	OMIM: 601832; MGI: 99687; HomoloGene: 133570; GeneCards: RPL29; OMA:RPL29 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.2 Start 51,993,522 bp[1] End 51,995,895 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 106,306,653 bp[2] End 106,308,767 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium skin of leg left ovary skin of abdomen right ovary ganglionic eminence right uterine tube right adrenal cortex muscle of thigh subcutaneous adipose tissue Top expressed in urinary bladder ventricular zone lip tail of embryo genital tubercle ganglionic eminence thymus lens adrenal gland epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding RNA binding structural constituent of ribosome cadherin binding Cellular component intracellular anatomical structure cytosol membrane cytosolic large ribosomal subunit ribosome Biological process translational initiation SRP-dependent cotranslational protein targeting to membrane nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cytoplasmic translation embryo implantation protein biosynthesis viral transcription rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6159 19944 Ensembl ENSG00000162244 ENSMUSG00000048758 UniProt P47914 P47915 RefSeq (mRNA) NM_000992 NM_009082 NM_001324533 NM_001324534 RefSeq (protein) NP_000983 NP_001311462 NP_001311463 NP_033108 Location (UCSC) Chr 3: 51.99 – 52 Mb Chr 9: 106.31 – 106.31 Mb PubMed search [3] [4]
Wikidata
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60S ribosomal protein L29 is a protein that in humans is encoded by the RPL29 gene.^[5][6]

Function[edit]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]

Interactions[edit]

RPL29 has been shown to interact with BLMH.^[7]

References[edit]

Further reading[edit]

External links[edit]

• Overview of all the structural information available in the PDB for UniProt: P47914 (60S ribosomal protein L29) at the PDBe-KB.

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