Contents

EIF4H

Protein-coding gene in the species Homo sapiens

EIF4H
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DNG
Identifiers
Aliases	EIF4H, WBSCR1, WSCR1, eIF-4H, eukaryotic translation initiation factor 4H
External IDs	OMIM: 603431; MGI: 1341822; HomoloGene: 32536; GeneCards: EIF4H; OMA:EIF4H - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.23 Start 74,174,231 bp[1] End 74,197,122 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 74.71 cM Start 134,648,575 bp[2] End 134,668,344 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland skin of leg C1 segment body of pancreas muscle layer of sigmoid colon gastrocnemius muscle gastric mucosa prefrontal cortex skin of abdomen cerebellar hemisphere Top expressed in internal carotid artery external carotid artery primitive streak medullary collecting duct Paneth cell left lung lobe vestibular membrane of cochlear duct Gonadal ridge motor neuron vestibular sensory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function translation factor activity, RNA binding protein binding nucleic acid binding ribosomal small subunit binding RNA strand-exchange activity helicase activity RNA strand annealing activity RNA binding translation initiation factor activity cadherin binding Cellular component cytoplasm perinuclear region of cytoplasm cytosol eukaryotic translation initiation factor 4F complex membrane polysome Biological process translational initiation viral process developmental growth sexual reproduction regulation of translational initiation protein biosynthesis eukaryotic translation initiation factor 4F complex assembly formation of translation preinitiation complex cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7458 22384 Ensembl ENSG00000106682 ENSMUSG00000040731 UniProt Q15056 Q9WUK2 RefSeq (mRNA) NM_022170 NM_031992 NM_033561 NM_001312867 RefSeq (protein) NP_071496 NP_114381 NP_001299796 NP_291039 Location (UCSC) Chr 7: 74.17 – 74.2 Mb Chr 5: 134.65 – 134.67 Mb PubMed search [3] [4]
Wikidata
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Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene.^[5][6][7]

This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.^[7]

EIF4H appears analogous to drr-2inC. elegans which regulates the mTOR pathway and affects longevity.^[8]

References[edit]

Further reading[edit]

External links[edit]

• Overview of all the structural information available in the PDB for UniProt: Q9WUK2 (Mouse Eukaryotic translation initiation factor 4H) at the PDBe-KB.

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