Contents

Mitochondrial ribosomal protein L28

Protein-coding gene in the species Homo sapiens

MRPL28
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y
Identifiers
Aliases	MRPL28, MAAT1, p15, mitochondrial ribosomal protein L28
External IDs	OMIM: 604853; MGI: 1915861; HomoloGene: 4693; GeneCards: MRPL28; OMA:MRPL28 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 366,969 bp[1] End 371,289 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 26,342,474 bp[2] End 26,345,587 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart left testis right testis right frontal lobe putamen nucleus accumbens prefrontal cortex caudate nucleus Brodmann area 9 cingulate gyrus Top expressed in cardiac muscle tissue of left ventricle interventricular septum right kidney Ileal epithelium embryo epithelium of lens otic vesicle epiblast embryo right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrion cytosol mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10573 68611 Ensembl ENSG00000086504 ENSMUSG00000024181 UniProt Q13084 Q4TT37 Q9D1B9 RefSeq (mRNA) NM_006428 NM_024227 RefSeq (protein) NP_006419 NP_077189 Location (UCSC) Chr 16: 0.37 – 0.37 Mb Chr 17: 26.34 – 26.35 Mb PubMed search [3] [4]
Wikidata
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39S ribosomal protein L28, mitochondrial is a protein that in humans is encoded by the MRPL28 gene.^[5][6][7]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% proteintorRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion.^[7]

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Further reading[edit]

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