Contents

40S ribosomal protein S13

Protein-coding gene in the species Homo sapiens

RPS13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS13, S13, ribosomal protein S13
External IDs	OMIM: 180476; MGI: 1915302; HomoloGene: 128182; GeneCards: RPS13; OMA:RPS13 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.1 Start 17,074,388 bp[1] End 17,077,715 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F1 Start 115,930,740 bp[2] End 115,933,430 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte ganglionic eminence lymph node left ovary right ovary canal of the cervix gonad gallbladder uterine tube endometrium Top expressed in epiblast embryo embryo lens ventricular zone spleen ganglionic eminence thymus primary oocyte neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function small ribosomal subunit rRNA binding structural constituent of ribosome protein binding mRNA binding 5.8S rRNA binding RNA binding mRNA 5'-UTR binding Cellular component cytosol ribosome membrane focal adhesion intracellular anatomical structure cytosolic small ribosomal subunit nucleolus extracellular exosome nucleus nucleoplasm extracellular matrix postsynaptic density Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative regulation of RNA splicing protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6207 68052 Ensembl ENSG00000110700 ENSMUSG00000090862 UniProt P62277 P62301 RefSeq (mRNA) NM_001017 NM_026533 RefSeq (protein) NP_001008 NP_080809 Location (UCSC) Chr 11: 17.07 – 17.08 Mb Chr 7: 115.93 – 115.93 Mb PubMed search [3] [4]
Wikidata
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40S ribosomal protein S13 is a protein that in humans is encoded by the RPS13 gene.^[5][6][7]

Function[edit]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

Interactions[edit]

RPS13 has been shown to interact with PDCD4.^[8]

References[edit]

Further reading[edit]

External links[edit]

• Overview of all the structural information available in the PDB for UniProt: P62277 (40S ribosomal protein S13) at the PDBe-KB.

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