Filamin B, beta (FLNB), also known as Filamin B, beta (truncated actin binding protein 278 homolog), is a cytoplasmic protein which in humans is encoded by the FLNB gene.
FLNB regulates intracellular communication and signalling by cross-linking the protein actin to allow direct communication between the cell membrane and cytoskeletal network, to control and guide proper skeletal development.[5]
Mutations in the FLNB gene are involved in several lethal bone dysplasias, including boomerang dysplasia and atelosteogenesis type I.[6][7][8]
FLNB has been shown to interact with GP1BA,[9] Filamin,[10] FBLIM1,[11] PSEN1,[12] CD29[13] and PSEN2.[12]
PDB gallery
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2di8: Solution structure of the 19th filamin domain from human Filamin-B
2di9: Solution structure of the 9th filamin domain from human Filamin-B
2dia: Solution structure of the 10th filamin domain from human Filamin-B
2dib: Solution structure of the 11th filamin domain from human Filamin-B
2dic: Solution structure of the 12th filamin domain from human Filamin-B
2dj4: Solution structure of the 13th filamin domain from human Filamin-B
2dlg: Solution structure of the 20th Filamin domain from human Filamin-B
2dmb: Solution structure of the 15th Filamin domain from human Filamin-B
2dmc: Solution structure of the 18th Filamin domain from human Filamin-B
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Proteins of the cytoskeleton
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See also: cytoskeletal defects |