Profilin-1 is a protein that in humans is encoded by the PFN1 gene.[5][6]
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome.[7] Mutations in this gene may be a rare cause of amyotrophic lateral sclerosis, also called Lou Gehrig's disease.[8][9][10][11][12][13][14][15][16][17][18][19][20]
Profilin 1 has been shown to interact with:
PDB gallery
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1awi: HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE
1cf0: HUMAN PLATELET PROFILIN COMPLEXED WITH AN L-PRO10-IODOTYROSINE PEPTIDE
1cjf: PROFILIN BINDS PROLINE-RICH LIGANDS IN TWO DISTINCT AMIDE BACKBONE ORIENTATIONS
1fik: HUMAN PLATELET PROFILIN I CRYSTALLIZED IN LOW SALT
1fil: HUMAN PLATELET PROFILIN I CRYSTALLIZED IN HIGH SALT ACTIN-BINDING PROTEIN
1hlu: STRUCTURE OF BOVINE BETA-ACTIN-PROFILIN COMPLEX WITH ACTIN BOUND ATP PHOSPHATES SOLVENT ACCESSIBLE
1pfl: REFINED SOLUTION STRUCTURE OF HUMAN PROFILIN I
1pne: CRYSTALLIZATION AND STRUCTURE DETERMINATION OF BOVINE PROFILIN AT 2.0 ANGSTROMS RESOLUTION
2btf: THE STRUCTURE OF CRYSTALLINE PROFILIN-BETA-ACTIN
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Proteins of the cytoskeleton
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Nonhuman |
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See also: cytoskeletal defects |