Unconventional myosin-Va is a motor protein in charge of the intracellular transport of vesicles, organelles and protein complexes along the actin filaments.[5][6][7] In humans it is coded for by the MYO5A gene.[8][9][10]
In the presence of cargo adapters and calcium, unconventional myosin Va is present in an elongated and active state. It has an N-terminal head domain and a C-terminal tail domain. The actin-binding head (N-Terminal) is an ATP-dependent motor domain that transmits changes from the active site to the light chain lever arm. The C-terminal globular domain (GB) decides the Myosin class and moderate the cargo transport. Also, the GB interacts with other cargo specific proteins. Myosin Va is highly expressed in neurons and melanocytes.[5][6]
MYO5A has been shown to interact with DYNLL1,[11] RAB27A,[12][13] DYNLL2,[11][14] RPGRIP1L,[15] and Rab3A.[6]
PDB gallery
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1oe9: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN - NUCLEOTIDE-FREE
1w7i: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITHOUT NUCLEOTIDE SOAKED IN 10 MM MGADP
1w7j: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN + ADP-BEFX - NEAR RIGOR
1w8j: CRYSTAL STRUCTURE OF MYOSIN V MOTOR DOMAIN -NUCLEOTIDE-FREE
2ix7: STRUCTURE OF APO-CALMODULIN BOUND TO UNCONVENTIONAL MYOSIN V
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Proteins of the cytoskeleton
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See also: cytoskeletal defects |