Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene.[5][6]
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[6]
PDB gallery
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1mv4: TM9A251-284: A Peptide Model of the C-Terminus of a Rat Striated Alpha Tropomyosin
2g9j: Complex of TM1a(1-14)Zip with TM9a(251-284): a model for the polymerization domain (""overlap region"") of tropomyosin
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Proteins of the cytoskeleton
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See also: cytoskeletal defects |
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it. |