Contents

MYH3

Protein-coding gene in the species Homo sapiens

MYH3
Identifiers
Aliases	MYH3, HEMHC, MYHC-EMB, MYHSE1, SMHCE, DA2A, DA2B, DA8, myosin, heavy chain 3, skeletal muscle, embryonic, myosin heavy chain 3, CPSKF1A, DA2B3, CPSKF1B, CPSFS1B, CPSFS1A
External IDs	OMIM: 160720; MGI: 1339709; HomoloGene: 20553; GeneCards: MYH3; OMA:MYH3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 10,628,526 bp[1] End 10,657,309 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 40.59 cM Start 66,969,126 bp[2] End 66,993,117 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm muscle of thigh Skeletal muscle tissue of rectus abdominis gastrocnemius muscle testicle seminal vesicula sural nerve glutes Top expressed in extraocular muscle epidermis upper arm muscle of arm mesenchyme synovial joint atrium ankle joint autopod region hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding calmodulin binding microfilament motor activity actin binding cytoskeletal motor activity ATP binding myosin phosphatase activity actin filament binding Cellular component cytoplasm cytosol sarcomere myofibril myosin filament muscle myosin complex extracellular exosome myosin complex contractile fiber Biological process skeletal muscle contraction muscle organ development actin filament-based movement ATP metabolic process embryonic limb morphogenesis muscle filament sliding sarcomere organization face morphogenesis protein dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4621 17883 Ensembl ENSG00000109063 ENSMUSG00000020908 UniProt P11055 P13541 RefSeq (mRNA) NM_002470 NM_001099635 RefSeq (protein) NP_002461 NP_001093105 Location (UCSC) Chr 17: 10.63 – 10.66 Mb Chr 11: 66.97 – 66.99 Mb PubMed search [3] [4]
Wikidata
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Myosin-3 is a protein that in humans is encoded by the MYH3 gene.^[5][6]

Function[edit]

Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysisofATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes,^[7] Freeman–Sheldon syndrome and Sheldon–Hall syndrome.^[6]

References[edit]

Further reading[edit]

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