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Tubulin beta-2A chain

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TUBB2A

Identifiers

Aliases

TUBB2A, CDCBM5, TUBB, TUBB2, dJ40E16.7, tubulin beta 2A class IIa

External IDs

OMIM: 615101; MGI: 107861; HomoloGene: 134314; GeneCards: TUBB2A; OMA:TUBB2A - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p25.2	Start	3,153,497 bp^[1]
Band	6p25.2	End	3,157,544 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13 A3.3\|13 14.03 cM	Start	34,258,257 bp^[2]
Band	13 A3.3\|13 14.03 cM	End	34,261,990 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

pons

frontal pole

spinal ganglia

Pars compacta

superior vestibular nucleus

Brodmann area 10

Brodmann area 23

orbitofrontal cortex

pars reticulata

Top expressed in

barrel cortex

trigeminal ganglion

piriform cortex

medial dorsal nucleus

anterior amygdaloid area

ventral tegmental area

supraoptic nucleus

ventromedial nucleus

lateral hypothalamus

subiculum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding GTP binding structural constituent of cytoskeleton protein binding GTPase activity
Cellular component	cytoplasm extracellular vesicle microtubule extracellular exosome cytoskeleton nucleus microtubule cytoskeleton
Biological process	microtubule-based process cytoskeleton organization microtubule cytoskeleton organization mitotic cell cycle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7280


22151

Ensembl


ENSG00000137267


ENSMUSG00000058672

UniProt


Q13885


Q7TMM9

RefSeq (mRNA)


NM_001310315 NM_001069


NM_009450

RefSeq (protein)


NP_001060 NP_001297244


NP_033476

Location (UCSC)

Chr 6: 3.15 – 3.16 Mb

Chr 13: 34.26 – 34.26 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Tubulin beta-2A chain is a protein that in humans is encoded by the TUBB2A gene.^[5]^[6]

References

[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137267 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058672 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S (Oct 2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.

^ "Entrez Gene: TUBB2A tubulin, beta 2A".

Waterman-Storer CM, Karki S, Holzbaur EL (1995). "The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1)". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1634–8. Bibcode:1995PNAS...92.1634W. doi:10.1073/pnas.92.5.1634. PMC 42574. PMID 7878030.

Carr D, Knull H (1993). "Aldolase-tubulin interactions: removal of tubulin C-terminals impairs interactions". Biochem. Biophys. Res. Commun. 195 (1): 289–93. doi:10.1006/bbrc.1993.2043. PMID 8103323.

Volz A, Weiss E, Trowsdale J, Ziegler A (1994). "Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction". Hum. Genet. 93 (1): 42–6. doi:10.1007/BF00218911. PMID 8270253. S2CID 7853030.

Paschal BM, Holzbaur EL, Pfister KK, et al. (1993). "Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin". J. Biol. Chem. 268 (20): 15318–23. doi:10.1016/S0021-9258(18)82472-3. PMID 8325901.

Linhartová I, Dráberová E, Viklický V, Dráber P (1993). "Distribution of non-class-III beta-tubulin isoforms in neuronal and non-neuronal cells". FEBS Lett. 320 (1): 79–82. doi:10.1016/0014-5793(93)81662-J. PMID 8462682. S2CID 38579660.

Huby RD, Carlile GW, Ley SC (1996). "Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells". J. Biol. Chem. 270 (51): 30241–4. doi:10.1074/jbc.270.51.30241. PMID 8530437.

Bosc C, Cronk JD, Pirollet F, et al. (1996). "Cloning, expression, and properties of the microtubule-stabilizing protein STOP". Proc. Natl. Acad. Sci. U.S.A. 93 (5): 2125–30. Bibcode:1996PNAS...93.2125B. doi:10.1073/pnas.93.5.2125. PMC 39921. PMID 8700896.

Tian G, Huang Y, Rommelaere H, et al. (1996). "Pathway leading to correctly folded beta-tubulin". Cell. 86 (2): 287–96. doi:10.1016/S0092-8674(00)80100-2. PMID 8706133. S2CID 18359371.

Tokito MK, Howland DS, Lee VM, Holzbaur EL (1997). "Functionally distinct isoforms of dynactin are expressed in human neurons". Mol. Biol. Cell. 7 (8): 1167–80. doi:10.1091/mbc.7.8.1167. PMC 275970. PMID 8856662.

Kinnunen T, Kaksonen M, Saarinen J, et al. (1998). "Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth". J. Biol. Chem. 273 (17): 10702–8. doi:10.1074/jbc.273.17.10702. PMID 9553134.

Niethammer M, Valtschanoff JG, Kapoor TM, et al. (1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron. 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. PMID 9581762. S2CID 16068361.

Rasmussen RK, Ji H, Eddes JS, et al. (1998). "Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins". Electrophoresis. 19 (5): 809–17. doi:10.1002/elps.1150190535. PMID 9629920. S2CID 21204230.

Ciruela F, Robbins MJ, Willis AC, McIlhinney RA (1999). "Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins: evidence for a direct interaction with tubulin". J. Neurochem. 72 (1): 346–54. doi:10.1046/j.1471-4159.1999.0720346.x. PMID 9886087. S2CID 3923065.

Chau MF, Radeke MJ, de Inés C, et al. (1999). "The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains". Biochemistry. 37 (51): 17692–703. doi:10.1021/bi9812118. PMID 9922135.