Contents

Mitochondrial ribosomal protein L18

Protein-coding gene in the species Homo sapiens

MRPL18
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y
Identifiers
Aliases	MRPL18, L18mt, MRP-L18, HSPC071, mitochondrial ribosomal protein L18
External IDs	OMIM: 611831; MGI: 1914931; HomoloGene: 8566; GeneCards: MRPL18; OMA:MRPL18 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 159,789,812 bp[1] End 159,798,436 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A1 Start 13,130,236 bp[2] End 13,135,232 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte olfactory bulb palpebral conjunctiva muscle of thigh anterior cingulate cortex mucosa of transverse colon smooth muscle tissue prefrontal cortex C1 segment Top expressed in blastocyst primary oocyte secondary oocyte embryo heart proximal tubule quadriceps femoris muscle epiblast embryo morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome 5S rRNA binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome intracellular anatomical structure extracellular space mitochondrial large ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination rRNA import into mitochondrion protein biosynthesis transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29074 67681 Ensembl ENSG00000112110 ENSMUSG00000057388 UniProt Q9H0U6 Q9CQL5 RefSeq (mRNA) NM_014161 NM_001318817 NM_026310 RefSeq (protein) NP_001305746 NP_054880 NP_080586 Location (UCSC) Chr 6: 159.79 – 159.8 Mb Chr 17: 13.13 – 13.14 Mb PubMed search [3] [4]
Wikidata
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39S ribosomal protein L18, mitochondrial is a protein that in humans is encoded by the MRPL18 gene.^[5][6][7]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% proteintorRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L18P ribosomal protein family. Three polymorphic sites exist in this gene, one of which is three nt in length which causes an extra aa near the N-terminus.^[7]

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