Contents

Mitochondrial ribosomal protein L33

Protein-coding gene in the species Homo sapiens

MRPL33
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL33, C2orf1, L33mt, MRP-L33, RPL33L, mitochondrial ribosomal protein L33
External IDs	OMIM: 610059; MGI: 2137225; HomoloGene: 81733; GeneCards: MRPL33; OMA:MRPL33 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.2 Start 27,771,717 bp[1] End 27,988,087 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 31,754,279 bp[2] End 31,821,728 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal cortex gastrocnemius muscle left ventricle right auricle apex of heart biceps brachii popliteal artery tibial arteries thoracic aorta Top expressed in granulocyte yolk sac morula muscle of thigh atrioventricular valve intercostal muscle right kidney ventricular zone blastocyst endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome Cellular component mitochondrial inner membrane ribosome intracellular anatomical structure mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9553 66845 Ensembl ENSG00000243147 ENSMUSG00000106918 UniProt O75394 Q9CQP0 RefSeq (mRNA) NM_145330 NM_004891 NM_025796 RefSeq (protein) NP_004882 NP_663303 NP_080072 Location (UCSC) Chr 2: 27.77 – 27.99 Mb Chr 5: 31.75 – 31.82 Mb PubMed search [3] [4]
Wikidata
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39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene.^[5]

Function[edit]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% proteintorRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described.^[5]

References[edit]

Further reading[edit]

External links[edit]

• Overview of all the structural information available in the PDB for UniProt: O75394 (Human 39S ribosomal protein L33, mitochondrial (MRPL33)) at the PDBe-KB.

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