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Names | |
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Preferred IUPAC name
N,N-Diethyl-N-methyl-3-[(methylcarbamoyl)oxy]anilinium iodide | |
Other names
AR-16, TL-1217 | |
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3D model (JSmol) |
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Properties | |
C13H21IN2O2 | |
Molar mass | 364.227 g·mol−1 |
Related compounds | |
Related compounds |
Neostigmine Miotine |
Hazards | |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose) |
129 μg/kg (Subcutaneous, mice)[1] 75 μg/kg (Subcutaneous, cats)[1] 75 μg/kg (Subcutaneous, dogs)[1] 150 μg/kg (Subcutaneous, rabbits)[1] 122.5 μg/kg (Intramuscular, rats)[2] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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T-1123 is a carbamate-based acetylcholinesterase inhibitor. It was investigated as a chemical warfare agent starting in 1940. It does not go through the blood-brain barrier due to the charge on quaternary nitrogen. The antidote is atropine.[3] T-1123 is a quaternary ammonium ion. A phenyl carbamate ester is bonded in the meta position to the nitrogen on a diethylmethyl amine. The chloride and methylsulfate salt of T-1123 is TL-1299 and TL-1317, respectively.
T-1123 can be produced from m-diethylaminophenol, methyl isocyanate and methyl iodide. First, m-diethylaminophenol is reacted with methyl isocyanate to produce a methylcarbamate. The resulting methylcarbamate is then reacted with methyl iodide to produce T-1123.[1]
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