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Importing Wikidata short description: "Protein-coding gene in the species Homo sapiens" (Shortdesc helper)
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
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'''Cadherin EGF LAG seven-pass G-type receptor 2''' is a [[protein]] that in humans is encoded by the ''CELSR2'' [[gene]].<ref name="pmid9693030">{{cite journal | vauthors = Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O | title = Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening | journal = Genomics | volume = 51 | issue = 1 | pages = 27–34 |date=Sep 1998 | pmid = 9693030 | doi = 10.1006/geno.1998.5341 }}</ref><ref name="entrez"/> |
'''Cadherin EGF LAG seven-pass G-type receptor 2''' is a [[protein]] that in humans is encoded by the ''CELSR2'' [[gene]].<ref name="pmid9693030">{{cite journal | vauthors = Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O | title = Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening | journal = Genomics | volume = 51 | issue = 1 | pages = 27–34 |date=Sep 1998 | pmid = 9693030 | doi = 10.1006/geno.1998.5341 }}</ref><ref name="entrez"/> |
Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.[5][6]
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.[6]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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