Contents

F2RL2

Protein-coding gene in the species Homo sapiens

F2RL2
Identifiers
Aliases	F2RL2, PAR-3, PAR3, coagulation factor II thrombin receptor like 2
External IDs	OMIM: 601919; MGI: 1298208; HomoloGene: 36151; GeneCards: F2RL2; OMA:F2RL2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.3 Start 76,615,482 bp[1] End 76,623,413 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D1|13 50.38 cM Start 95,833,361 bp[2] End 95,839,247 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium retinal pigment epithelium skin of thigh gallbladder islet of Langerhans testicle skin of hip gastric mucosa smooth muscle tissue nipple Top expressed in lumbar spinal ganglion right lobe of liver gastrula blood tibiofemoral joint yolk sac granulocyte embryo tail of embryo submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thrombin-activated receptor activity protein binding signal transducer activity phosphatidylinositol phospholipase C activity G protein-coupled receptor activity Cellular component integral component of membrane extracellular region plasma membrane integral component of plasma membrane apical plasma membrane membrane protein-containing complex Biological process platelet activation hemostasis thrombin-activated receptor signaling pathway blood coagulation response to wounding signal transduction positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2151 14064 Ensembl ENSG00000164220 ENSMUSG00000021675 UniProt O00254 O08675 RefSeq (mRNA) NM_004101 NM_001256566 NM_010170 RefSeq (protein) NP_001243495 NP_004092 NP_034300 Location (UCSC) Chr 5: 76.62 – 76.62 Mb Chr 13: 95.83 – 95.84 Mb PubMed search [3] [4]
Wikidata
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Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene.

Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to G proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.^[5]

• Protease-activated receptor

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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