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Contents

(Top) 1 See also 2 References 3 External links

Relaxin receptor

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relaxin/insulin-like family peptide receptor 1

Identifiers

Symbol

RXFP1

Alt. symbols

LGR7

Other data

Chr. 4 q31.3

Search for
Structures	Swiss-model
Domains	InterPro

relaxin/insulin-like family peptide receptor 2

Identifiers

Symbol

RXFP2

Alt. symbols

LGR8, GREAT, GPR106, INSL3R

Other data

Chr. 13 q12.3

Search for
Structures	Swiss-model
Domains	InterPro

relaxin/insulin-like family peptide receptor 3

Identifiers

Symbol

RXFP3

Alt. symbols

RLN3R1, SALPR, GPCR135

Other data

Chr. 5 p15.1-p14

Search for
Structures	Swiss-model
Domains	InterPro

relaxin/insulin-like family peptide receptor 4

Identifiers

Symbol

RXFP4

Alt. symbols

GPR100, GPCR142, RLN3R2

Other data

Chr. 1 q22

Search for
Structures	Swiss-model
Domains	InterPro

The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.^[1]^[2]

Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are activated or inhibited by the receptor.

receptor/gene	ligands	activates	inhibits
RXFP1	relaxin 1, relaxin 2, relaxin 3	adenylate cyclase, protein kinase A, protein kinase C, phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2)
RXFP2	relaxin 1, relaxin 2, insulin-like 3	adenylate cyclase
RXFP3	relaxin 3	Erk1/2 signaling	adenylate cyclase
RXFP4	relaxin 3, insulin-like 3		adenylate cyclase

See also[edit]

References[edit]

^ Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. S2CID 7466039.

^ Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ (2007). "Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways". Br. J. Pharmacol. 150 (6): 677–91. doi:10.1038/sj.bjp.0707140. PMC 2013861. PMID 17293890.

External links[edit]

"Relaxin Family Peptide Receptors: Motilin". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
relaxin+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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e

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

CysLT (1
2)
LTB4
- 1
- 2
FPRL1
OXE
Prostaglandin
- DP (1
- 2), EP (1
- 2
- 3
- 4), FP
Prostacyclin
Thromboxane

Other

Peptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Miscellaneous

Taste, bitter

TAS2R
- 1
- 3
- 4
- 5
- 7
- 8
- 9
- 10
- 13
- 14
- 16
- 19
- 20
- 30
- 31
- 38
- 39
- 40
- 41
- 42
- 43
- 45
- 46
- 50
- 60
Vomeronasal receptor type 1

Other

Class B: Secretin-like

ADGRB
- Brain-specific angiogenesis inhibitor
  - 1
  - 2
  - 3
ADGRC
- Cadherin
  - 1
  - 2
  - 3
ADGRE
- EMR
  - 1
  - 2
  - 3
- CD97
ADGRG
- 1
- 2
- 3
- 4
- 5
- 6
- 7
ADGRL
- Latrophilin
  - 1
  - 2
  - 3
- ELTD1

GPR (56
64
97
98
110
111
112
113
114
115
116
123
124
125
126
128
133
143
144
155
157)

Other

Class C: Metabotropic glutamate / pheromone

Taste, sweet

TAS1R
- 1
- 2
- 3
Vomeronasal receptor, type 2

Other

Calcium-sensing receptor
GABA_B (1
2)
Glutamate receptor (Metabotropic glutamate (1
2
3
4
5
6
7
8))
GPRC6A
GPR (156
158
179)
RAIG (1
2
3
4)

Class F: Frizzled & Smoothened

Frizzled

Frizzled (1
2
3
4
5
6
7
8
9
10)

Smoothened

Smoothened

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

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