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Metabotropic glutamate receptor 6

Mammalian protein found in humans

GRM6
Identifiers
Aliases	GRM6, CSNB1B, GPRC1F, MGLUR6, mGlu6, glutamate metabotropic receptor 6
External IDs	OMIM: 604096; MGI: 1351343; HomoloGene: 20232; GeneCards: GRM6; OMA:GRM6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 178,977,587 bp[1] End 178,996,206 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 50,741,512 bp[2] End 50,757,035 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle pancreatic ductal cell tibialis anterior muscle cerebellar hemisphere ganglionic eminence right hemisphere of cerebellum anterior pituitary deltoid muscle hypothalamus Ventricular system of neuraxis Top expressed in neural layer of retina embryo epiblast spleen thymus bone marrow lens islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glutamate receptor activity G protein-coupled receptor activity protein homodimerization activity signal transducer activity adenylate cyclase inhibiting G protein-coupled glutamate receptor activity protein binding Cellular component integral component of membrane Golgi apparatus cell projection endoplasmic reticulum membrane membrane Golgi membrane plasma membrane integral component of plasma membrane dendrite endoplasmic reticulum presynaptic membrane new growing cell tip Biological process G protein-coupled glutamate receptor signaling pathway detection of visible light locomotory behavior response to stimulus sensory perception of light stimulus detection of light stimulus involved in visual perception positive regulation of calcium ion import retina development in camera-type eye signal transduction visual perception chemical synaptic transmission regulation of synaptic transmission, glutamatergic adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2916 108072 Ensembl ENSG00000113262 ENSMUSG00000000617 UniProt O15303 Q5NCH9 RefSeq (mRNA) NM_000843 NM_173372 RefSeq (protein) NP_000834 NP_775548 Location (UCSC) Chr 5: 178.98 – 179 Mb Chr 11: 50.74 – 50.76 Mb PubMed search [3] [4]
Wikidata
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Glutamate receptor, metabotropic 6, also known as GRM6ormGluR6, is a protein which in humans is encoded by the GRM6 gene.^[5][6]

Function[edit]

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.^[5]

mGluR6 is specifically expressed in the retina, in a subtype of bipolar cells that depolarize in response to light, known as ON bipolar cells. These cells form synapses with photoreceptor cells, and detect the neurotransmitter glutamate via a GPCR signal transduction cascade. The glutamate receptor mGluR6 is located post-synaptically at the tips of the bipolar cell dendrites, and is responsible for initiating a signaling cascade that ultimately controls gating of the TRPM1 channel.^[7][8] In human patients, mutations in the GRM6 gene are associated with congenital stationary night blindness.^[9][10]

See also[edit]

• Metabotropic glutamate receptor

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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