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GPR144

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ADGRD2

Identifiers

Aliases

ADGRD2, PGR24, GPR144, adhesion G protein-coupled receptor D2

External IDs

HomoloGene: 130029; GeneCards: ADGRD2; OMA:ADGRD2 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q33.3	Start	124,450,451 bp^[1]
Band	9q33.3	End	124,478,589 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

parotid gland

triceps brachii muscle

vena cava

right ventricle

dorsal motor nucleus of vagus nerve

pituitary gland

anterior pituitary

lateral nuclear group of thalamus

inferior olivary nucleus

cerebellar vermis

n/a

More reference expression data

BioGPS


More reference expression data

Orthologs

Species

Human

Mouse

Entrez


347088


n/a

Ensembl


ENSG00000180264


n/a

UniProt


n a


n/a

RefSeq (mRNA)


NM_001161808 NM_182611 NM_001395425


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

Chr 9: 124.45 – 124.48 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Probable G-protein coupled receptor 144 is a protein that in humans is encoded by the GPR144 gene.^[3]^[4] This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterised by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[5]^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180264 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Entrez Gene: GPR144 G protein-coupled receptor 144".

^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

Further reading[edit]

Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.

Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.

Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)