BRS3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | BRS3, BB3, bombesin like receptor 3, BB3R, bombesin receptor subtype 3, BBR3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 300107; MGI: 1100501; HomoloGene: 1307; GeneCards: BRS3; OMA:BRS3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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The bombesin receptor subtype 3 also known as BRS-3orBB3[5] is a protein which in humans is encoded by the BRS3 gene.[6][7]
Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[7][8]
BB3 is a G protein-coupled receptor.[6]BB3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[6][9][10]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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