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GPR112

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ADGRG4

Identifiers

Aliases

ADGRG4, PGR17, RP1-299I16, GPR112, adhesion G protein-coupled receptor G4

External IDs

MGI: 2685213; HomoloGene: 72131; GeneCards: ADGRG4; OMA:ADGRG4 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xq26.3	Start	136,300,963 bp^[1]
Band	Xq26.3	End	136,416,890 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	X\|X A6	Start	55,915,523 bp^[2]
Band	X\|X A6	End	56,046,918 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

duodenum

jejunal mucosa

left uterine tube

gastric mucosa

Achilles tendon

urinary bladder

body of uterus

right coronary artery

fundus

tibial arteries

Top expressed in

proximal tubule

secondary oocyte

primary oocyte

zygote

right kidney

human kidney

embryo

duodenum

jejunum

placenta

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity
Cellular component	integral component of membrane membrane intracellular anatomical structure integral component of plasma membrane
Biological process	G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


139378


236798

Ensembl


ENSG00000156920


ENSMUSG00000053852

UniProt


Q8IZF6


n/a

RefSeq (mRNA)


NM_153834


NM_001033327 NM_001110790 NM_001362885

RefSeq (protein)


NP_722576


n/a

Location (UCSC)

Chr X: 136.3 – 136.42 Mb

Chr X: 55.92 – 56.05 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene.^[5]^[6] GPR112 is a member of the adhesion GPCR family.^[7]^[8] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[9]

GPR112 is expressed in human enterochromaffin cells^[10] and in the mouse intestine.^[11] The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules.^[11] GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.^[10]

References

[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156920 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053852 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Entrez Gene: GPR112 G protein-coupled receptor 112".

^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

^ Langenhan T, Aust G, Hamann J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.

^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

^ ^a ^b Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH, Lloyd R, Vasmatzis G, Demoulin JB, Giandomenico V (Feb 2009). "Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas". Modern Pathology. 22 (2): 261–72. doi:10.1038/modpathol.2008.174. PMID 18953328. S2CID 22334557.

^ ^a ^b Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

External links

[edit]

Adhesion GPCR consortium

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)